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Cobalt complexes bearing scorpionate ligands: Synthesis, characterization, cytotoxicity and DNA cleavage

2012Journal article Restricted access
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dc.contributor.authorSilva, Telma F. S.
dc.contributor.authorMartins, Luisa
dc.contributor.authorGuedes da Silva, Maria de Fátima
dc.contributor.authorFernandes, Alexandra R.
dc.contributor.authorSilva, Ana
dc.contributor.authorBorralho, Pedro M.
dc.contributor.authorSantos, Susana
dc.contributor.authorRodrigues, Cecília M. P.
dc.contributor.authorPombeiro, Armando
dc.date.accessioned2015-09-08T13:58:12Z
dc.date.available2015-09-08T13:58:12Z
dc.date.issued2012
dc.description.abstractA number of novel, water-stable redox-active cobalt complexes of the C-functionalized tripodal ligands tris(pyrazolyl)methane XC(pz)(3) (X = HOCH2, CH2OCH2Py or CH2OSO2Me) are reported along with their effects on DNA. The compounds were isolated as air-stable solids and fully characterized by IR and FIR spectroscopies, ESI-MS(+/-), cyclic voltammetry, controlled potential electrolysis, elemental analysis and, in a number of cases, also by single-crystal X-ray diffraction. They showed moderate cytotoxicity in vitro towards HCT116 colorectal carcinoma and HepG2 hepatocellular carcinoma human cancer cell lines. This viability loss is correlated with an increase of tumour cell lines apoptosis. Reactivity studies with biomolecules, such as reducing agents, H2O2, plasmid DNA and UV-visible titrations were also performed to provide tentative insights into the mode of action of the complexes. Incubation of Co(II) complexes with pDNA induced double strand breaks, without requiring the presence of any activator. This pDNA cleavage appears to be mediated by O-centred radical species.por
dc.identifier.citationSILVA, T. F. S., [et al] – Cobalt complexes bearing scorpionate ligands: Synthesis, characterization, cytotoxicity and DNA cleavage. Dalton Transactions. ISSN: 1477-9226. Vol. 41, nr. 41 (2012), pp. 12888-12897por
dc.identifier.doi10.1039/c2dt11577h
dc.identifier.issn1477-9226
dc.identifier.urihttp://hdl.handle.net/10400.21/5097
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherRoyal Soc Chemistrypor
dc.relationFCT- PEst-OE/QUI/UI0100/2011
dc.relationFCT - SFRH/BD/48087/2008
dc.relationFCT- SFRH/BPD/65212/2009
dc.subjectSingle-pot hydrocarboxylationpor
dc.subjectOrganic molecular-crystalspor
dc.subjectPeroxidative oxidationpor
dc.subjectCarboxylic-acidspor
dc.subjectMetal-freepor
dc.subjectIn-vitropor
dc.subjectTris(Pyrazolyl)Methane ligandspor
dc.subjectAqueous systemspor
dc.subjectMild conditionspor
dc.subjectWater clusterspor
dc.titleCobalt complexes bearing scorpionate ligands: Synthesis, characterization, cytotoxicity and DNA cleavagepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage12897por
oaire.citation.issue41por
oaire.citation.startPage12888por
oaire.citation.titleDalton Transactionspor
oaire.citation.volume41por
person.familyNameMartins
person.familyNamePombeiro
person.givenNameLuisa
person.givenNameArmando
person.identifier637885
person.identifier.ciencia-idE218-E297-A4EA
person.identifier.ciencia-id8311-38FA-CEFB
person.identifier.orcid0000-0002-5403-9352
person.identifier.orcid0000-0001-8323-888X
person.identifier.ridG-6210-2011
person.identifier.ridI-5945-2012
person.identifier.scopus-author-id8650947800
person.identifier.scopus-author-id7006067269
rcaap.rightsclosedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication8ed70b09-b4d3-4a5d-9f75-12b13a332204
relation.isAuthorOfPublication6d18ff2e-5c33-4010-b1e7-964c72349813
relation.isAuthorOfPublication.latestForDiscovery6d18ff2e-5c33-4010-b1e7-964c72349813

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