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Development of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powder

2022Journal article Restricted access
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dc.contributor.authorTrindade, Daniela
dc.contributor.authorMoura, Carla
dc.contributor.authorCalado, Cecília
dc.contributor.authorÂngelo, David
dc.contributor.authorAlves, Nuno
dc.date.accessioned2022-03-08T13:42:56Z
dc.date.available2022-03-08T13:42:56Z
dc.date.issued2022
dc.description.abstractThe temporomandibular joint disc (TMJd) is an avascular and fibrocartilaginous tissue with low regeneration capacities. To date there is no permanent solution upon its damage. So, our group hypothesise that the combination of a synthetic material [poly(ethylene glycol) diacrylate, PEGDA] and decellularised matrices may be the answer, since it has the advantage of retaining extracellular matrix (ECM) components. For this purpose, lamb TMJd were decellularised with ethanol (96%)/ acetone (99.5%) followed by an analysis to the ECM obtained. Afterwards, different concentrations of ECM powder were added to the PEGDA to obtain hybrid hydrogels. Their swelling capacities and mechanical behaviour (hydrated or dry) were assessed. Results show a reduction of the proteoglycans in the disc, except in the posterior region. Dried hydrogels with 2% ECM powder are the ones with the closer compressive modulus to the native disc, along with greater viscoelastic capacity, representing a possible approach to a TMJd replacement.pt_PT
dc.description.versioninfo:eu-repo/semantics/draftpt_PT
dc.identifier.citationTRINDADE, Daniela; [et al] – Development of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powder. World Review of Science, Technology and Sustainable. Development. ISSN 1741-2242. (2022), pp. 1-13.pt_PT
dc.identifier.doi10.1504/WRSTSD.2022.10044167pt_PT
dc.identifier.issn1741-2242
dc.identifier.urihttp://hdl.handle.net/10400.21/14406
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInderscience Publisherspt_PT
dc.subjectDecellularisationpt_PT
dc.subjectExtracellular matrix poderpt_PT
dc.subjectPoly(ethylene glycol) diacrylate hydrogelspt_PT
dc.subjectTemporomandibular joint discpt_PT
dc.titleDevelopment of a biocompatible hydrogel based on native temporomandibular joint extracellular matrix powderpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage13pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleWorld Review of Science, Technology and Sustainable. Developmentpt_PT
person.familyNameTrindade
person.familyNameMonteiro de Moura
person.familyNameCalado
person.familyNameÂngelo
person.familyNameAlves
person.givenNameDaniela Alexandra
person.givenNameCarla Sofia
person.givenNameCecília
person.givenNameDavid
person.givenNameNuno
person.identifier130332
person.identifier452149
person.identifier.ciencia-id6316-1507-A39A
person.identifier.ciencia-id671C-8FEC-A14A
person.identifier.ciencia-id9418-E320-3177
person.identifier.ciencia-id2C1B-F1D5-5A08
person.identifier.ciencia-id311E-1559-8F6C
person.identifier.orcid0000-0003-3621-7095
person.identifier.orcid0000-0003-2610-1005
person.identifier.orcid0000-0002-5264-9755
person.identifier.orcid0000-0001-8411-9946
person.identifier.orcid0000-0002-5016-0868
person.identifier.ridE-2102-2014
person.identifier.ridN-4073-2013
person.identifier.scopus-author-id6603163260
person.identifier.scopus-author-id7006403383
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery211bbc46-4ae3-4c8d-b063-783296d301a4

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