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Peculiarities of neurostimulation by intense nanosecond pulsed electric fields: how to avoid firing in peripheral nerve fibers

2021-06-30Journal article Open access
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dc.contributor.authorKim, Vitalii
dc.contributor.authorGudvangen, Emily
dc.contributor.authorKondratiev, Oleg
dc.contributor.authorRedondo, Luis
dc.contributor.authorXiao, Shu
dc.contributor.authorPakhomov, Andrei
dc.date.accessioned2021-10-07T14:13:56Z
dc.date.available2021-10-07T14:13:56Z
dc.date.issued2021-06-30
dc.description.abstractIntense pulsed electric fields (PEF) are a novel modality for the efficient and targeted ablation of tumors by electroporation. The major adverse side effects of PEF therapies are strong involuntary muscle contractions and pain. Nanosecond-range PEF (nsPEF) are less efficient at neurostimulation and can be employed to minimize such side effects. We quantified the impact of the electrode configuration, PEF strength (up to 20 kV/cm), repetition rate (up to 3 MHz), bi- and triphasic pulse shapes, and pulse duration (down to 10 ns) on eliciting compound action potentials (CAPs) in nerve fibers. The excitation thresholds for single unipolar but not bipolar stimuli followed the classic strength-duration dependence. The addition of the opposite polarity phase for nsPEF increased the excitation threshold, with symmetrical bipolar nsPEF being the least efficient. Stimulation by nsPEF bursts decreased the excitation threshold as a power function above a critical duty cycle of 0.1%. The threshold reduction was much weaker for symmetrical bipolar nsPEF. Supramaximal stimulation by high-rate nsPEF bursts elicited only a single CAP as long as the burst duration did not exceed the nerve refractory period. Such brief bursts of bipolar nsPEF could be the best choice to minimize neuromuscular stimulation in ablation therapies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationKIM, Vitalii; [et al] – Peculiarities of neurostimulation by intense nanosecond pulsed electric fields: how to avoid firing in peripheral nerve fibers. International Journal of Molecular Sciences. eISSN 1422-0067. Vol. 22, N.º 13 (2021), pp. 1-18pt_PT
dc.identifier.doi10.3390/ijms22137051pt_PT
dc.identifier.eissn1422-0067
dc.identifier.urihttp://hdl.handle.net/10400.21/13836
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationA9550-15-1-0517 - AFOSR MURI grantpt_PT
dc.subjectExcitationpt_PT
dc.subjectElectropermeabilizationpt_PT
dc.subjectElectrostimulationpt_PT
dc.subjectnsPEFpt_PT
dc.subjectNerve stimulationpt_PT
dc.subjectElectroporationpt_PT
dc.subjectNanoporationpt_PT
dc.titlePeculiarities of neurostimulation by intense nanosecond pulsed electric fields: how to avoid firing in peripheral nerve fiberspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage18pt_PT
oaire.citation.issue13pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume22pt_PT
person.familyNameKim
person.familyNameGudvangen
person.familyNameRedondo
person.familyNamePakhomov
person.givenNameVitalii
person.givenNameEmily
person.givenNameLuis
person.givenNameAndrei
person.identifier1017419
person.identifier.ciencia-id5E13-9730-4651
person.identifier.orcid0000-0003-0699-5582
person.identifier.orcid0000-0003-3316-1970
person.identifier.orcid0000-0002-2381-4627
person.identifier.orcid0000-0003-3816-3860
person.identifier.ridA-3078-2009
person.identifier.scopus-author-id7003990641
person.identifier.scopus-author-id7102906860
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication38fd8d0b-3466-4a7f-8ee4-acfc942d79c1
relation.isAuthorOfPublication1d3e3435-66c8-4d32-8ffc-d5798a8533a4
relation.isAuthorOfPublication9250ebe7-9069-4915-b47f-930233eb692f
relation.isAuthorOfPublication.latestForDiscovery475d6f6b-c70d-4f3a-a1ef-9f6a68fd5525

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