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DNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexescontaining heteroaromatic ligands

2011-02Journal article Open access
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dc.contributor.authorMoreno, Virtudes
dc.contributor.authorFont-Bardia, Merce
dc.contributor.authorCalvet, Teresa
dc.contributor.authorJulia Lorenzo
dc.contributor.authorAviles, Francesc Xavier
dc.contributor.authorGarcia, M. Helena
dc.contributor.authorMorais, Tânia S.
dc.contributor.authorValente, Andreia
dc.contributor.authorRobalo, Maria Paula
dc.date.accessioned2013-01-31T17:27:31Z
dc.date.available2013-01-31T17:27:31Z
dc.date.issued2011-02
dc.description.abstractFour ruthenium(II) complexes with the formula [Ru(eta(5)-C(5)H(5))(PP)L][CF(3)SO(3)], being (PP = two triphenylphosphine molecules), L = 1-benzylimidazole, 1; (PP = two triphenylphosphine molecules), L = 2,2'bipyridine, 2; (PP = two triphenylphosphine molecules), L = 4-Methylpyridine, 3; (PP = 1,2-bis(diphenylphosphine) ethane), L = 4-Methylpyridine, 4, were prepared, in view to evaluate their potentialities as antitumor agents. The compounds were completely characterized by NMR spectroscopy and their crystal and molecular structures were determined by X-ray diffraction. Electrochemical studies were carried out giving for all the compounds quasi-reversible processes. The images obtained by atomic force microscopy (AFM) suggest interaction with pBR322 plasmid DNA. Measurements of the viscosity of solutions of free DNA and DNA incubated with different concentrations of the compounds confirmed this interaction. The cytotoxicity of compounds 1234 was much higher than that of cisplatin against human leukemia cancer cells (HL-60 cells). IC(50) values for all the compounds are in the range of submicromolar amounts. Apoptotic death percentage was also studied resulting similar than that of cisplatin. (C) 2010 Elsevier Inc. All rights reserved.por
dc.identifier.citationMORENO, Virtudes; FONT-BARDIA, Merce; CALVET, Teresa; LORENZO, Júlia; AVILES, Francesc X.; GARCIA, M. Helena; MORAIS, Tânia S.; VALENTE, Andreia; ROBALO, M. Paula - DNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexescontaining heteroaromatic ligands. Journal of Inorganic Biochemistry. ISSN 0162-0134. Vol. 105, n.º2 (2011) p. 241-249.por
dc.identifier.issn0162-0134
dc.identifier.urihttp://hdl.handle.net/10400.21/2148
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevier Science INCpor
dc.subjectRuthenium (II)por
dc.subjectCyclopentadienyl derivativespor
dc.subjectX-ray structurespor
dc.subjectAntiproliferative assayspor
dc.subjectIn-Vitro cytotoxicitypor
dc.subjectCancer-cell-growthpor
dc.subjectNami-Apor
dc.subjectArene complexespor
dc.subjectCrystal-structurepor
dc.subjectChemistrypor
dc.subjectInhibitionpor
dc.subjectProliferationpor
dc.subjectExpressionpor
dc.subjectAssaypor
dc.titleDNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexescontaining heteroaromatic ligandspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNew Yorkpor
oaire.citation.endPage249por
oaire.citation.issue2por
oaire.citation.startPage241por
oaire.citation.titleJournal of Inorganic Biochemistrypor
oaire.citation.volume105por
person.familyNameFont-Bardia
person.familyNameCalvet
person.familyNameLorenzo
person.familyNameAviles
person.familyNameAnselmo Viegas Garcia
person.familyNameRobalo
person.givenNameMerce
person.givenNameTeresa
person.givenNameJulia
person.givenNameFrancesc Xavier
person.givenNameMaria Helena
person.givenNameMaria Paula
person.identifier111223
person.identifierH-2175-­2013
person.identifier.ciencia-id0513-9D07-9012
person.identifier.ciencia-id5414-9AEF-4194
person.identifier.ciencia-idE11C-A704-9C18
person.identifier.orcid0000-0002-7892-8744
person.identifier.orcid0000-0002-4058-7171
person.identifier.orcid0000-0001-5659-6008
person.identifier.orcid0000-0002-1399-6789
person.identifier.orcid0000-0002-4344-2218
person.identifier.orcid0000-0002-8200-6910
person.identifier.ridM-3836-2014
person.identifier.ridE-9015-2011
person.identifier.ridF-3482-2019
person.identifier.ridB-2002-2012
person.identifier.scopus-author-id9233760700
person.identifier.scopus-author-id7005688779
person.identifier.scopus-author-id6507884466
person.identifier.scopus-author-id9269662100
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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