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Ruthenium carboranyl complexes with 2,2 '-bipyridine derivatives for potential bimodal therapy application

2020-04-28Journal article Open access
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dc.contributor.authorGonçalves Teixeira, Ricardo
dc.contributor.authorMarques, Fernanda
dc.contributor.authorRobalo, M. Paula
dc.contributor.authorFontrodona, Xavier
dc.contributor.authorGarcia, M. Helena
dc.contributor.authorGeninatti Crich, Simonetta
dc.contributor.authorVinas, Clara
dc.contributor.authorValente, Andreia
dc.date.accessioned2021-01-27T18:16:21Z
dc.date.available2021-01-27T18:16:21Z
dc.date.issued2020-04-28
dc.description.abstractRuthenium complexes of carboranyl ligands offer the possibility of dual action (chemo + radiotherapy) that might result in significant clinical benefits. In that frame, we describe herein the development of ruthenium-carboranyl complexes bearing bipyridyl derivatives with the general formula [3-CO-3,3-{kappa(2)-4,4 '-R-2-2,2 '-bipy}-closo-3,1,2-RuC2B9H11] (R = CH3,RuCB1or R = CH2OH,RuCB2). Both compounds crystallized in the monoclinic system, showing the expected three-legged piano stool structure. The ruthenacarboranes are stable in cell culture media and were tested against two cell lines that have shown favorable clinical responses with BNCT, namely melanoma (A375) and glioblastoma (U87).RuCB1shows no cytotoxic activity up to 100 mu M whileRuCB2showed moderate activity for both cell lines. Cell distribution assays showed thatRuCB2presents high boron internalization that is proportional to the concentration used indicating thatRuCB2presents features to be further studied as a potential anticancer bimodal agent (chemo + radiotherapy).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTEIXEIRA, Ricardo G.; [et al] – Ruthenium carboranyl complexes with 2,2 '-bipyridine derivatives for potential bimodal therapy application. RSC Advances. eISSN 2046-2069. Vol. 10, N.º 28 (2020), pp. 16266-16276pt_PT
dc.identifier.doi10.1039/d0ra01522apt_PT
dc.identifier.eissn2046-2069
dc.identifier.urihttp://hdl.handle.net/10400.21/12716
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationUIDB/00100/2020 - FCTpt_PT
dc.relation17104 STRATAGEM - European Cooperation in Science and Technology (COST)pt_PT
dc.relationCM1302 - European Cooperation in Science and Technology (COST)pt_PT
dc.relationCTQ2016-75150-R - MINECOpt_PT
dc.relation2017 SGR 1720 - Generalitat de Catalunyapt_PT
dc.relationPTDC/QUI-QIN/28662/2017 - FCTpt_PT
dc.relationSFRH/BD/135830/2018 - FCTpt_PT
dc.relationCEECIND/01974/2017 - CEECIND 2017 Initiativept_PT
dc.relation.publisherversionhttps://pubs.rsc.org/en/content/articlepdf/2020/ra/d0ra01522apt_PT
dc.subjectRuthenium carboranylpt_PT
dc.subjectChemo + radiotherapypt_PT
dc.subjectClinical benefitspt_PT
dc.subjectMonoclinic systempt_PT
dc.titleRuthenium carboranyl complexes with 2,2 '-bipyridine derivatives for potential bimodal therapy applicationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04349%2F2013/PT
oaire.citation.endPage16276pt_PT
oaire.citation.issue28pt_PT
oaire.citation.startPage16266pt_PT
oaire.citation.titleRSC Advancespt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream5876
person.familyNameGonçalves Teixeira
person.familyNameMarujo Marques
person.familyNameRobalo
person.familyNameFontrodona
person.familyNameAnselmo Viegas Garcia
person.familyNameGeninatti Crich
person.familyNameValente
person.givenNameRicardo
person.givenNameFernanda
person.givenNameMaria Paula
person.givenNamexavier
person.givenNameMaria Helena
person.givenNameSimonetta
person.givenNameAndreia
person.identifierJ-9790-2013
person.identifierH-2175-­2013
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person.identifier.orcid0000-0002-1028-0486
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person.identifier.orcid0000-0002-8200-6910
person.identifier.orcid0000-0002-9873-1332
person.identifier.orcid0000-0002-4344-2218
person.identifier.orcid0000-0003-2998-5424
person.identifier.orcid0000-0002-3370-208X
person.identifier.ridL-7014-2017
person.identifier.ridB-2002-2012
person.identifier.ridD-9251-2011
person.identifier.scopus-author-id16402591700
person.identifier.scopus-author-id9269662100
person.identifier.scopus-author-id6507884466
person.identifier.scopus-author-id6602612944
person.identifier.scopus-author-id23570219600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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