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Antiproliferative activity of heterometallic sodium and potassium-dioxidovanadium(V) polymers

2019-11Journal article Restricted access
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dc.contributor.authorSutradhar, Manas
dc.contributor.authorAlegria, Elisabete
dc.contributor.authorFerretti, Francesco
dc.contributor.authorRaposo, Luís R
dc.contributor.authorGuedes Da Silva, M. Fátima C.
dc.contributor.authorBaptista, Pedro
dc.contributor.authorFernandes, Alexandra
dc.contributor.authorPombeiro, Armando
dc.date.accessioned2019-10-21T08:45:56Z
dc.date.available2019-10-21T08:45:56Z
dc.date.issued2019-11
dc.description.abstractThe syntheses of the heterometallic sodium and potassium-dioxidovanadium 2D polymers, [NaVO2(1 kappa NOO';2 kappa O ''-L)(H2O)](n), (1) and [KVO2(1 kappa NOO';2 kappa O';3 kappa O ''-L)(EtOH)](n) (2) (where the kappa notation indicates the coordinating atoms of the polydentate ligand L) derived from (3,5-di-tert-butyl-2-hydroxybenzylidene)-2-hydroxybenzohydrazide (H2L) are reported. The polymers were characterized by IR, NMR, elemental analysis and single crystal X-ray diffraction analysis. The antiproliferative potential of 1 and 2 was examined towards four human cancer cell lines (ovarian carcinoma, A2780, colorectal carcinoma, HCT116, prostate carcinoma, PC3 and breast adenocarcinoma, MCF-7cell lines) and normal human fibroblasts. Complex 1 and 2 showed the highest cytotoxic activity against A2780 cell line (IC50 8.2 and 11.3 mu M, respectively) with 1 > 2 and an IC50 in the same range as cisplatin (IC50 3.4 mu M; obtained in the same experimental conditions) but, interestingly, with no cytotoxicity to healthy human fibroblasts for concentrations up to 75 mu M. This high cytotoxicity of 1 in ovarian cancer cells and its low cytotoxicity in healthy cells demonstrates its potential for further biological studies. Our results suggest that both complexes induce ovarian carcinoma cell death via apoptosis and autophagy, but autophagy is the main biological cause of the reduction of viability observed and that ROS (reactive oxygen species) may play an important role in triggering cell death.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSUTRADHAR, Manas; [et al] – Antiproliferative activity of heterometallic sodium and potassium-dioxidovanadium(V) polymers. Journal of Inorganic Biochemistry. ISSN 0162-0134. Vol. 200 (2019), pp. 1-7pt_PT
dc.identifier.doi10.1016/j.jinorgbio.2019.110811pt_PT
dc.identifier.issn0162-0134
dc.identifier.issn1873-3344
dc.identifier.urihttp://hdl.handle.net/10400.21/10589
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPTDC/QEQ-ERQ/1648/2014 - FCTpt_PT
dc.relationUID/QUI/00100/2019 - FCTpt_PT
dc.relationDL/57/2017 - FCTpt_PT
dc.relationIST-ID/102/2018 - FCT/ISTpt_PT
dc.relationUID/Multi/04378/2019 - FCTpt_PT
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dc.subjectDioxidovanadium(V)pt_PT
dc.subjectAroylhydrazonept_PT
dc.subjectX-ray structurept_PT
dc.subjectAntiproliferative agentpt_PT
dc.titleAntiproliferative activity of heterometallic sodium and potassium-dioxidovanadium(V) polymerspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage7pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Inorganic Biochemistrypt_PT
oaire.citation.volume200pt_PT
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