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First heterobimetallic Cu(i)-dppf complexes designed for anticancer applications: synthesis, structural characterization and cytotoxicity

2019-08-21Journal article Restricted access
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dc.contributor.authorBravo, Catarina
dc.contributor.authorM. Paula Robalo
dc.contributor.authorMarques, Fernanda
dc.contributor.authorFernandes, Alexandra
dc.contributor.authorSequeira, Diogo A.
dc.contributor.authorM. Fatima M. Piedade
dc.contributor.authorGarcia, M. Helena
dc.contributor.authorVilla De Brito, Maria José
dc.contributor.authorMorais, Tânia
dc.date.accessioned2019-09-25T08:35:10Z
dc.date.available2019-09-25T08:35:10Z
dc.date.issued2019-08-21
dc.description.abstractA new family of eight heterobimetallic Cu(i)-dppf complexes of general formula [Cu(dppf)L][BF4] with dppf = 1,1 '-bis(diphenylphosphino)ferrocene and L representing N,N-, N,O- and N,S-heteroaromatic bidentate ligands have been synthesized and fully characterized by classical analytical, spectroscopic and electrochemical methods. The single crystal structures of [Cu(dppf)(pBI)][BF4] (6), [Cu(dppf)(dpytz)][BF4] (7) and [Cu(dppf)(5-Aphen)][BF4] (8) complexes (where pBI = 2-(2-pyridyl)benzimidazole, dpytz = 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine and 5-Aphen = 1,10-phenanthrolin-5-amine) were determined by X-ray diffraction studies. Cytotoxicity of all complexes was evaluated in two human breast adenocarcinoma cell lines (MCF7 and MDAMB231). All the complexes exhibit high cytotoxicity against both human breast cancer cells with IC50 values far lower than those found for the antitumor drug cisplatin in the same cell lines. The IC50 values on primary healthy fibroblasts are of the same order of magnitude as those found for the tumoral cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBRAVO, Catarina; [et al] – First heterobimetallic Cu(i)-dppf complexes designed for anticancer applications: synthesis, structural characterization and cytotoxicity. New Journal of Chemistry. ISSN 1144-0546. Vol. 43, N.º 31 (2019), pp. 12308-12317pt_PT
dc.identifier.doi10.1039/c9nj02068cpt_PT
dc.identifier.issn1144-0546
dc.identifier.issn1369-9261
dc.identifier.urihttp://hdl.handle.net/10400.21/10521
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationUID/Multi/04378/2019 - FCTpt_PT
dc.relationPOCI-01-0145-FEDER-007728 - Unidade de Ciências Biomoleculares Aplicadas - UCIBIO by the ERDF under the PT2020 Partnership Agreementpt_PT
dc.relationCEECIND/00630/2017 - CEECIND 2017 Initiativept_PT
dc.relationTARGETING TUMORS WITH INNOVATIVE METAL PEPTIDE COMPLEXAS: IMPROVING EFFICACY IN ANTICANCER DRUGS
dc.relation.publisherversionhttps://pubs.rsc.org/en/content/articlepdf/2019/nj/c9nj02068cpt_PT
dc.subjectHeterobimetallicpt_PT
dc.subjectCytotoxicitypt_PT
dc.titleFirst heterobimetallic Cu(i)-dppf complexes designed for anticancer applications: synthesis, structural characterization and cytotoxicitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTARGETING TUMORS WITH INNOVATIVE METAL PEPTIDE COMPLEXAS: IMPROVING EFFICACY IN ANTICANCER DRUGS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00100%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04349%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F93513%2F2013/PT
oaire.citation.endPage12317pt_PT
oaire.citation.issue31pt_PT
oaire.citation.startPage12308pt_PT
oaire.citation.titleNew Journal of Chemistrypt_PT
oaire.citation.volume43pt_PT
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameBravo
person.familyNameRobalo
person.familyNameFernandes
person.familyNameMonteiro Martins Minas da Piedade
person.familyNameAnselmo Viegas Garcia
person.familyNameVilla de Brito
person.familyNameMorais
person.givenNameCatarina
person.givenNameMaria Paula
person.givenNameAlexandra
person.givenNameMaria de Fátima
person.givenNameMaria Helena
person.givenNameMaria José
person.givenNameTânia
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person.identifier.orcid0000-0002-4344-2218
person.identifier.orcid0000-0002-7571-6076
person.identifier.orcid0000-0003-0233-8243
person.identifier.ridU-5188-2017
person.identifier.ridB-2002-2012
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person.identifier.ridN-3910-2015
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person.identifier.scopus-author-id9269662100
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person.identifier.scopus-author-id25930490800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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