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Crosslinked bacterial cellulose hydrogels for biomedical applications

2022-08-15Journal article Open access
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dc.contributor.authorAlmeida, Ana
dc.contributor.authorSaraiva, João N.
dc.contributor.authorCavaco, Gonçalo
dc.contributor.authorPortela, Raquel
dc.contributor.authorLeal, Catarina R.
dc.contributor.authorSobral, Rita
dc.contributor.authorAlmeida, Pedro L.
dc.date.accessioned2022-02-22T15:11:35Z
dc.date.available2022-02-22T15:11:35Z
dc.date.issued2022-08-15
dc.description.abstractThe skin, fundamental barrier that protects internal tissues, prevents pathogen invasion, and maintains the body fluid equilibrium, may be compromised upon traumas, such as incisions and burns. The healing process of such wounds is costly and usually hindered by the patient’s physiological conditions, associated diseases, inflammation and external factors, namely bacterial infections. Recently, increasing attention has been given to bacterial cellulose-based membranes to be applied as dressings for healing purposes. Bacterial cellulose is an attractive biomaterial due to its unique structural characteristics such as high porosity, high water retention capacity, high mechanical strength, low density, and biodegradability. One drawback of bacterial cellulose hydrogels is that, after the first dehydration, the water retention capacity is hindered. In this work we produced, modified, and characterized hydrated and de-hydrated BC membranes. Two crosslinking methods were adopted (using citric acid and epichlorohydrin as crosslinking agents), and the results obtained from the characterizations such as water retention capacity, mechanical properties or contact angle were compared to those of unmodified bacterial cellulose. We demonstrate that the cross-linked bacterial cellulose membranes present physical properties suitable to be used as surgical and burn wound dressings when hydrated, or as exuding wound dressings, diapers dressing or sanitary pads when dehydrated.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationALMEIDA, Ana P. C.; [et al] – Crosslinked bacterial cellulose hydrogels for biomedical applications. European Polymer Journal. ISSN 0014-3057. Vol. 177 (2022), pp. 1-10.pt_PT
dc.identifier.doi10.1016/j.eurpolymj.2022.111438pt_PT
dc.identifier.eissn1873-1945
dc.identifier.issn0014-3057
dc.identifier.urihttp://hdl.handle.net/10400.21/14330
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0014305722004426?via%3Dihubpt_PT
dc.subjectBiomaterialspt_PT
dc.subjectBiomedical applicationspt_PT
dc.subjectBacterial celulosept_PT
dc.subjectWound dressingspt_PT
dc.subjectPhysical characterizationpt_PT
dc.titleCrosslinked bacterial cellulose hydrogels for biomedical applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleEuropean Polymer Journalpt_PT
person.familyNameAlmeida
person.familyNameCordeiro Cavaco
person.familyNamePortela
person.familyNameMarques Mendes Almeida da Rosa Leal
person.familyNameSobral
person.familyNameMarques de Almeida
person.givenNameAna
person.givenNameGonçalo Francisco
person.givenNameRaquel
person.givenNameCatarina
person.givenNameRita
person.givenNamePedro
person.identifier2405257
person.identifierA-2814-2009
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person.identifier.ciencia-id0218-71B2-2DE0
person.identifier.orcid0000-0003-4984-0759
person.identifier.orcid0000-0002-5003-604X
person.identifier.orcid0000-0002-5559-9554
person.identifier.orcid0000-0001-5871-4936
person.identifier.orcid0000-0003-4533-7531
person.identifier.orcid0000-0001-7356-8455
person.identifier.ridE-6523-2019
person.identifier.ridH-4710-2011
person.identifier.ridB-4356-2009
person.identifier.scopus-author-id57191899755
person.identifier.scopus-author-id57201234562
person.identifier.scopus-author-id7005379280
person.identifier.scopus-author-id6507285825
person.identifier.scopus-author-id57190384213
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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