Repository logo
 
Publication

Design and anticancer properties of new water-soluble ruthenium–cyclopentadienyl complexes

2022-07Journal article Open access
Simple item page
dc.contributor.authorMorais, Tânia
dc.contributor.authorMarques, Fernanda
dc.contributor.authorMadeira, Paulo J. Amorim
dc.contributor.authorRobalo, M.P.
dc.contributor.authorGarcia, Maria Helena
dc.date.accessioned2023-02-02T12:59:47Z
dc.date.available2023-02-02T12:59:47Z
dc.date.issued2022-07
dc.description.abstractRuthenium complexes are emerging as one of the most promising classes of complexes for cancer therapy. However, their limited aqueous solubility may be the major limitation to their potential clinical application. In view and to contribute to the progress of this field, eight new water-soluble Ru(II) organometallic complexes of general formula [RuCp(mTPPMS)n(L)] [CF3SO3], where mTPPMS = diphenylphosphane-benzene-3-sulfonate, for n = 2, L is an imidazole-based ligand (imidazole, 1-benzylimidazole, 1-butylimidazole, (1-(3 aminopropyl)imidazole), and (1-(4-methoxyphenyl)imidazole)), and for n = 1, L is a bidentate heteroaromatic ligand (2-benzoylpyridine, (di(2-pyridyl)ketone), and (1,2-(2-pyridyl)benzo-[b]thiophene)) were synthesized and characterized. The new complexes were fully characterized by NMR, FT-IR, UV–vis., ESI-HRMS, and cyclic voltammetry, which confirmed all the proposed molecular structures. The antiproliferative potential of the new Ru(II) complexes was evaluated on MDAMB231 breast adenocarcinoma, A2780 ovarian carcinoma, and HT29 colorectal adenocarcinoma cell lines, showing micromolar (MDAMB231 and HT29) and submicromolar (A2780) IC50 values. The interaction of complex 6 with human serum albumin (HSA) and fatty-acid-free human serum albumin (HSAfaf) was evaluated by fluorescence spectroscopy techniques, and the results revealed that the ruthenium complex strongly quenches the intrinsic fluorescence of albumin in both cases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMORAIS, T. S.; MARQUES, F.; MADEIRA, P. J. A.; ROBALO M. Paula; GARCIA, M. H. - Design and Anticancer Properties of New Water-Soluble Ruthenium–Cyclopentadienyl Complexes. Pharmaceuticals. ISSN 1424-8247. Vol. 15, July (2022) p. 1-19.pt_PT
dc.identifier.doidoi.org/10.3390/ph15070862pt_PT
dc.identifier.issn1424-8247
dc.identifier.urihttp://hdl.handle.net/10400.21/15465
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2305-7084/6/4/63pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectWater-solublept_PT
dc.subjectRutheniumpt_PT
dc.subjectCyclopentadienylpt_PT
dc.subjectAnticancerpt_PT
dc.subjectAlbuminpt_PT
dc.titleDesign and anticancer properties of new water-soluble ruthenium–cyclopentadienyl complexespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-QIN%2F0146%2F2020/PT
oaire.citation.endPage19pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePharmaceuticalspt_PT
oaire.citation.volume15pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameMorais
person.familyNameMarujo Marques
person.familyNameMadeira
person.familyNameRobalo
person.givenNameTânia
person.givenNameFernanda
person.givenNamePaulo
person.givenNameMaria Paula
person.identifierJ-9790-2013
person.identifier.ciencia-idB61A-A9D4-08CC
person.identifier.ciencia-id1C11-A0C7-418A
person.identifier.ciencia-idE11C-A704-9C18
person.identifier.orcid0000-0003-0233-8243
person.identifier.orcid0000-0001-8440-5299
person.identifier.orcid0000-0001-9922-7392
person.identifier.orcid0000-0002-8200-6910
person.identifier.ridD-8824-2011
person.identifier.ridB-8914-2008
person.identifier.ridB-2002-2012
person.identifier.scopus-author-id25930490800
person.identifier.scopus-author-id16402591700
person.identifier.scopus-author-id24475068300
person.identifier.scopus-author-id9269662100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication09da3711-2a20-4ce9-92b2-7c8165d73095
relation.isAuthorOfPublication9233f544-e8ce-49f2-84b5-d3c119139b84
relation.isAuthorOfPublicationf77864c5-db54-432c-adcb-405bc970d0d4
relation.isAuthorOfPublication823a9498-17ab-451f-bb8f-56338643ac0c
relation.isAuthorOfPublication.latestForDiscovery09da3711-2a20-4ce9-92b2-7c8165d73095
relation.isProjectOfPublication6bc6fcc0-3eae-47ff-8400-cbd9429cee73
relation.isProjectOfPublication.latestForDiscovery6bc6fcc0-3eae-47ff-8400-cbd9429cee73

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Design and Anticancer Properties of New Water-Soluble.pdf
Size:
2.24 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ISEL - Eng. Quim. Biol. - Artigos