Publication
Variability of neutrophil-activating protein among Helicobacter pylori strains
| dc.contributor.author | Calado, Cecília | |
| dc.date.accessioned | 2022-03-07T10:25:06Z | |
| dc.date.available | 2022-03-07T10:25:06Z | |
| dc.date.issued | 2021-01 | |
| dc.description.abstract | The Helicobacter pylori neutrophil activating protein (NAP) presents relevant inflammatory and immunomodulatory activity and has consequently been explored as a diagnosis and therapeutic target. In the present work, nap gene sequences, retrieved from H. pylori isolated world-wide, were analyzed, a high genetic diversity (with 88% of alleles) being observed in accordance with other virulence factors. The phylogenetic analysis did not reveal the separation of strains per geographical region according to a bacterial panmictic population. When compared to other genes of virulence factors of H. pylori, such as the vacuolating cytotoxin A (vacA), nap presents slightly lower genetic variability, concerning the number of alleles and polymorphic sites, pointing to a possible lower pressure of the host immune system. The nap genetic diversity is associated to a high proportion of synonymous substitutions in relation to non-synonymous substitutions, pointing to equilibrium between the need for antigenic diversity as a mechanism to escape the host immune system and the maintenance of the proteins function. All this information could be put to good use when planning the NAP application as a therapeutic or diagnostic target. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | CALADO, Cecília R. C. – Variability of neutrophil-activating protein among Helicobacter pylori strains. Romanian Archives of Microbiology and Immunology. ISSN 1222-3891. Vol. 80, N.º 1 (2021), pp. 43-50. | pt_PT |
| dc.identifier.doi | 10.54044/RAMI.2021.01.06 | pt_PT |
| dc.identifier.issn | 1222-3891 | |
| dc.identifier.uri | http://hdl.handle.net/10400.21/14385 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Cantacuzino Institute Bucharest | pt_PT |
| dc.relation.publisherversion | https://roami.ro/wp-content/uploads/2021/08/Revista-Cantacuzino_issue1_January-March_2021_articol5.pdf | pt_PT |
| dc.subject | Helicobacter pylori | pt_PT |
| dc.subject | Genetic variability | pt_PT |
| dc.subject | Neutrophil-activating protein | pt_PT |
| dc.title | Variability of neutrophil-activating protein among Helicobacter pylori strains | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIO%2F69242%2F2006/PT | |
| oaire.citation.endPage | 50 | pt_PT |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 43 | pt_PT |
| oaire.citation.title | Romanian Archives of Microbiology and Immunology | pt_PT |
| oaire.citation.volume | 80 | pt_PT |
| oaire.fundingStream | 3599-PPCDT | |
| person.familyName | Calado | |
| person.givenName | Cecília | |
| person.identifier | 130332 | |
| person.identifier.ciencia-id | 9418-E320-3177 | |
| person.identifier.orcid | 0000-0002-5264-9755 | |
| person.identifier.rid | E-2102-2014 | |
| person.identifier.scopus-author-id | 6603163260 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | closedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | e8577257-c64c-4481-9b2b-940fedb360cc | |
| relation.isAuthorOfPublication.latestForDiscovery | e8577257-c64c-4481-9b2b-940fedb360cc | |
| relation.isProjectOfPublication | e934d4a3-07d0-4c5d-8183-e76b3b0bf237 | |
| relation.isProjectOfPublication.latestForDiscovery | e934d4a3-07d0-4c5d-8183-e76b3b0bf237 |
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