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Numerical 3D modeling of heat transfer in human tissues for microwave radiometry monitoring of Brown fat metabolismo

2013-02-02Conference object Open access
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dc.contributor.authorRodrigues, Dário B.
dc.contributor.authorMaccarini, Paolo F.
dc.contributor.authorSalahi, Sara
dc.contributor.authorColebeck, Erin
dc.contributor.authorTopsakal, Erdem
dc.contributor.authorPereira, Pedro Jorge da Silva
dc.contributor.authorLimão-Vieira, Paulo
dc.contributor.authorStauffer, Paul R.
dc.date.accessioned2015-10-09T17:27:28Z
dc.date.available2015-10-09T17:27:28Z
dc.date.issued2013-02-02
dc.description.abstractBackground: Brown adipose tissue (BAT) plays an important role in whole body metabolism and could potentially mediate weight gain and insulin sensitivity. Although some imaging techniques allow BAT detection, there are currently no viable methods for continuous acquisition of BAT energy expenditure. We present a non-invasive technique for long term monitoring of BAT metabolism using microwave radiometry. Methods: A multilayer 3D computational model was created in HFSS™ with 1.5 mm skin, 3-10 mm subcutaneous fat, 200 mm muscle and a BAT region (2-6 cm3) located between fat and muscle. Based on this model, a log-spiral antenna was designed and optimized to maximize reception of thermal emissions from the target (BAT). The power absorption patterns calculated in HFSS™ were combined with simulated thermal distributions computed in COMSOL® to predict radiometric signal measured from an ultra-low-noise microwave radiometer. The power received by the antenna was characterized as a function of different levels of BAT metabolism under cold and noradrenergic stimulation. Results: The optimized frequency band was 1.5-2.2 GHz, with averaged antenna efficiency of 19%. The simulated power received by the radiometric antenna increased 2-9 mdBm (noradrenergic stimulus) and 4-15 mdBm (cold stimulus) corresponding to increased 15-fold BAT metabolism. Conclusions: Results demonstrated the ability to detect thermal radiation from small volumes (2-6 cm3) of BAT located up to 12 mm deep and to monitor small changes (0.5°C) in BAT metabolism. As such, the developed miniature radiometric antenna sensor appears suitable for non-invasive long term monitoring of BAT metabolism.pt_PT
dc.identifier.citationRODRIGUES, DÁRIO B.; [et al] – Numerical 3D modeling of heat transfer in human tissues for microwave radiometry monitoring of Brown fat metabolismo. In Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII. PubMed ID, 2013. ISSN: 1505-7422. Volume 85840Spt_PT
dc.identifier.doi10.1117/12.2004931
dc.identifier.issn1505-7422
dc.identifier.urihttp://hdl.handle.net/10400.21/5265
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPubMed IDpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subject3D modelingpt_PT
dc.subjectMicrowave radiometrypt_PT
dc.subjectTissuespt_PT
dc.subjectAntennaspt_PT
dc.subjectComputational modelingpt_PT
dc.subjectAbsorptionpt_PT
dc.subjectMultilayerspt_PT
dc.subjectRadiationpt_PT
dc.subjectSensorspt_PT
dc.subjectSkinpt_PT
dc.titleNumerical 3D modeling of heat transfer in human tissues for microwave radiometry monitoring of Brown fat metabolismopt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.titleProc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VIIpt_PT
oaire.citation.volume85840Spt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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