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New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells

2014-04Journal article Restricted access
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dc.contributor.authorValente, Andreia
dc.contributor.authorSantos, Ana Margarida
dc.contributor.authorCôrte-Real, Leonor
dc.contributor.authorRobalo, Maria Paula
dc.contributor.authorMoreno, Virtudes
dc.contributor.authorFont-Bardia, Merce
dc.contributor.authorCalvet, Teresa
dc.contributor.authorLorenzo, Julia
dc.contributor.authorGarcia, M. Helena
dc.date.accessioned2015-08-24T13:22:59Z
dc.date.available2015-08-24T13:22:59Z
dc.date.issued2014-04
dc.description.abstractA new family of "Fe-II(eta(5)-C5H5)" half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P2(1)/c and monoclinic P2(1)/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin. (C) 2014 Elsevier B.V. All rights reserved.por
dc.identifier.citationVALENTE, Andreia; [et al] – New Iron(II) Cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leucemia cancer cells. Journal of Organometallic Chemistry. ISSN: 0022-328X. Vol. 756 (2104), pp. 52-60por
dc.identifier.doi10.1016/j.jorganchem.2014.01.027
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.urihttp://hdl.handle.net/10400.21/4951
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevier Science SApor
dc.subjectIron(II)por
dc.subjectCyclopentadienylpor
dc.subjectAtomic Force Microscopy (AFM)por
dc.subjectLeukemia Cancer Cellspor
dc.subjectApoptosispor
dc.titleNew iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cellspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage60por
oaire.citation.startPage52por
oaire.citation.titleJournal of Organometallic Chemistrypor
oaire.citation.volume756por
person.familyNameValente
person.familyNameCôrte-Real
person.familyNameRobalo
person.familyNameFont-Bardia
person.familyNameCalvet
person.familyNameLorenzo
person.familyNameAnselmo Viegas Garcia
person.givenNameAndreia
person.givenNameLeonor
person.givenNameMaria Paula
person.givenNameMerce
person.givenNameTeresa
person.givenNameJulia
person.givenNameMaria Helena
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rcaap.rightsclosedAccesspor
rcaap.typearticlepor
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