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Syntheses, molecular structures, electrochemical behavior, theoretical study, and antitumor activities of organotin(IV) complexes containing 1-(4-chlorophenyl)-1-cyclopentanecarboxylato ligands

2011Journal article Restricted access
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dc.contributor.authorShang, Xianmei
dc.contributor.authorMeng, Xianggao
dc.contributor.authorAlegria, Elisabete
dc.contributor.authorLi, Qingshan
dc.contributor.authorGuedes Da Silva, M. Fátima C.
dc.contributor.authorKuznetsov, Maxim L.
dc.contributor.authorPombeiro, Armando
dc.date.accessioned2020-07-20T12:25:01Z
dc.date.available2020-07-20T12:25:01Z
dc.date.issued2011
dc.description.abstractThe organotin(IV) compounds [Me2Sn(L)2] (1), [Et2Sn(L)2]( 2), [nBu2Sn(L)2]( 3), [nOct2Sn(L)2]( 4), [Ph2Sn(L)2]( 5), and [PhOSnL]6 (6) have been synthesized from the reactions of 1-(4-chlorophenyl)-1-cyclopentanecarboxylic acid (HL) with the corresponding diorganotin(IV) oxide or dichloride. They were characterized by IR and multinuclear NMR spectroscopies, elemental analysis, cyclic voltammetry, and, for 2, 3, 4 and 6, single crystal X-ray diffraction analysis. While 1 5 are mononuclear diorganotin(IV) compounds, the X-ray diffraction of 6 discloses a hexameric drumlike structure with a prismatic Sn6O6 core. All these complexes undergo irreversible reductions and were screened for their in vitro antitumor activities toward HL-60,BGC-823,Bel-7402,and KB human cancer cel llines. Within the mononuclear compounds, the most active ones (3,5) are easiest to reduce (least cathodic reduction potentials), while the least active ones (1, 4) are the most difficult to reduce. Structural rearrangements (i.e., Sn O bond cleavages and trans-to-cis isomerization) induced by reduction, which eventually can favor the bioactivity, are disclosed by theoretical/electrochemical studies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSHANG, Xianmei; [et al] – Syntheses, molecular structures, electrochemical behavior, theoretical study, and antitumor activities of organotin(IV) complexes containing 1-(4-chlorophenyl)-1-cyclopentanecarboxylato ligands. Inorganic Chemistry. ISSN 0020-1669. Vol. 50, N.º 17 (2011), pp. 8158-8167pt_PT
dc.identifier.doi10.1021/ic200635gpt_PT
dc.identifier.issn0020-1669
dc.identifier.urihttp://hdl.handle.net/10400.21/12060
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherACS Publicationspt_PT
dc.relationPEst-OE/QUI/UI0100/ 2011 - FCTpt_PT
dc.relationNo. 2009ZX09103-104 - New Drug Development Programme from the Ministry of Science and Technology of Chinapt_PT
dc.subjectMolecular structurespt_PT
dc.subjectElectrochemical behaviorpt_PT
dc.subjectTheoretical studypt_PT
dc.subjectAntitumor activitiespt_PT
dc.titleSyntheses, molecular structures, electrochemical behavior, theoretical study, and antitumor activities of organotin(IV) complexes containing 1-(4-chlorophenyl)-1-cyclopentanecarboxylato ligandspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F44773%2F2008/PT
oaire.citation.endPage8167pt_PT
oaire.citation.issue17pt_PT
oaire.citation.startPage8158pt_PT
oaire.citation.titleInorganic Chemistrypt_PT
oaire.citation.volume50pt_PT
oaire.fundingStreamSFRH
person.familyNameShang
person.familyNameAlegria
person.familyNameGuedes da Silva
person.familyNameKuznetsov
person.familyNamePombeiro
person.givenNameXianmei
person.givenNameElisabete
person.givenNameM. Fátima C.
person.givenNameMaxim L.
person.givenNameArmando
person.identifier863202
person.identifier789079
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person.identifier.orcid0000-0001-5729-6189
person.identifier.orcid0000-0001-8323-888X
person.identifier.ridE-9945-2012
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person.identifier.ridI-5945-2012
person.identifier.scopus-author-id8315848300
person.identifier.scopus-author-id6701761571
person.identifier.scopus-author-id7102379353
person.identifier.scopus-author-id7006067269
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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