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The role of noise in the tumor dynamics under chemotherapy treatment

2021-11Journal article Open access
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dc.contributor.authorBashkirtseva, Irina
dc.contributor.authorRyashko, Lev
dc.contributor.authorDuarte, Jorge
dc.contributor.authorSeoane, Jesús M.
dc.contributor.authorSANJUAN, MIGUEL A. F.
dc.date.accessioned2021-11-16T10:11:50Z
dc.date.available2021-11-16T10:11:50Z
dc.date.issued2021-11
dc.description.abstractDynamical systems modeling tumor growth have been investigated to analyze the dynamics between tumor and healthy cells. Recent theoretical studies indicate that these interactions may lead to different dynamical outcomes under the effect of particular cancer therapies. In the present paper, we derive a system of nonlinear differential equations, in order to investigate solid tumors in vivo, taking into account the impact of chemotherapy on both tumor and healthy cells. We start by studying our model only in terms of deterministic dynamics under the variation of a drug concentration parameter. Later, with the introduction of noise, a stochastic model is used to analyze the impact of the unavoidable random fluctuations. As a result, new insights into noise-induced transitions are provided and illustrated in detail using techniques from dynamical systems and from the theory of stochastic processes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBASHKIRTSEVA, Irina; [et al] – The role of noise in the tumor dynamics under chemotherapy treatment. European Physical Journal Plus. eISSN 2190-5444. Vol. 136, N.º 11 (2021), pp. 1-13pt_PT
dc.identifier.doi10.1140/epjp/s13360-021-02061-zpt_PT
dc.identifier.eissn2190-5444
dc.identifier.urihttp://hdl.handle.net/10400.21/14009
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationPID2019-105554GB-I00 - European Regional Development Fund (ERDF, EU)pt_PT
dc.relation.publisherversionhttps://link.springer.com/content/pdf/10.1140/epjp/s13360-021-02061-z.pdfpt_PT
dc.subjectTumorpt_PT
dc.subjectHealthy cellspt_PT
dc.subjectCancer therapiespt_PT
dc.subjectChemotherapy treatmentpt_PT
dc.titleThe role of noise in the tumor dynamics under chemotherapy treatmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMAT%2F04459%2F2013/PT
oaire.citation.endPage13pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleEuropean Physical Journal Pluspt_PT
oaire.citation.volume136pt_PT
oaire.fundingStream5876
person.familyNameBashkirtseva
person.familyNameRyashko
person.familyNameDuarte
person.familyNameSANJUAN
person.givenNameIrina
person.givenNameLev
person.givenNameJorge
person.givenNameMIGUEL A. F.
person.identifier.ciencia-idBC1D-1E83-E2B2
person.identifier.orcid0000-0002-9254-8297
person.identifier.orcid0000-0002-0817-3753
person.identifier.orcid0000-0003-2641-3199
person.identifier.orcid0000-0003-3515-0837
person.identifier.ridQ-4291-2016
person.identifier.ridG-7261-2011
person.identifier.ridB-7709-2011
person.identifier.scopus-author-id55926812600
person.identifier.scopus-author-id35310049800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication4dbec82a-caa4-4662-b156-af73687e867f
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