Repository logo
 
Publication

Novel coating containing molybdenum oxide nanoparticles to reduce Staphylococcus aureus contamination on inanimate surfaces

2019-03-18Journal article Open access
Simple item page
dc.contributor.authorPiçarra, Susana
dc.contributor.authorLopes, Elizeth
dc.contributor.authorAlmeida, Pedro L.
dc.contributor.authorLencastre, Hermínia de
dc.contributor.authorAires-de-Sousa, Marta
dc.date.accessioned2019-05-06T08:11:03Z
dc.date.available2019-05-06T08:11:03Z
dc.date.issued2019-03-18
dc.description.abstractWe previously synthetized molybdenum oxide (MoO3) nanoparticles (NP) and showed their antibacterial activity against a representative collection of the most relevant bacterial species responsible for hospital-acquired infections, including Staphylococcus aureus. The aim of the present study was to prepare and characterize a novel coating with these MoO3 NP, confirm its mechanical stability, and investigate its biocidal effect to reduce S. aureus contamination on inanimate surfaces. In addition, the novel MoO3 NP coating was compared to a silver (Ag) NP coating synthetized by the same procedure. The MoO3 and Ag NP coatings were characterized in terms of their chemical structure by FT-IR, surface morphology by scanning electron microscopy, and mechanical properties by tensile and adhesion tests. The antimicrobial activity of the coatings was tested by following the loss of viability of S. aureus after 6h, 24h, 48h, and 72h exposure. MoO3 and Ag coatings exhibited surfaces of comparable morphologies and both presented elastomeric properties (tensile strength of similar to 420 kPa, Youngs modulus of similar to 48 kPa, and maximum elongation of similar to 12%), and excellent (classification of 5B) adhesion to glass, steel and polystyrene surfaces. The two coatings exhibited a good antibacterial activity (R) against S. aureus over time (R-MoO3 = 0.20.81; R-Ag = 0.612.37), although the effect of the Ag NP coating was more pronounced, especially at 72h (R-MoO3 = 0.81 vs R-Ag = 2.37). Noteworthy, contrary to the Ag NP coating, the MoO3 NP coating was colourless and transparent, avoiding undesired unaesthetic effects. The synthetized coating with NP of MoO3, which has low toxicity to humans, capability of biodegradation, and rapid excretion, can be applied onto most standard materials and therefore is a promising tool to reduce S. aureus contamination on usual inanimate surfaces found in healthcare and community environments.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPIÇARRA, Susana; [et al] – Novel coating containing molybdenum oxide nanoparticles to reduce Staphylococcus aureus contamination on inanimate surfaces. PLoS ONE. ISSN 1932-6203. Vol. 14, N.º 3 (2019), pp. 1-11pt_PT
dc.identifier.doi10.1371/journal.pone.0213151pt_PT
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.21/9934
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library of Sciencept_PT
dc.relationPTDC/DTP-EPI/0842/2014 - FEDER funds through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI)pt_PT
dc.relationPTDC/FIS/NAN/0117/2014 - FEDER funds through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI)pt_PT
dc.relationLISBOA-01-0145-FEDER-007660 - FEDER funds through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI)pt_PT
dc.relationUID/QUI/00100/2019 - FEDER funds through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI)pt_PT
dc.relation03/BI/2017 - FCTpt_PT
dc.relation.publisherversionhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0213151&type=printablept_PT
dc.subjectNovel coatingpt_PT
dc.subjectMolybdenum oxide nanoparticlespt_PT
dc.subjectStaphylococcus aureuspt_PT
dc.subjectInanimate surfacespt_PT
dc.titleNovel coating containing molybdenum oxide nanoparticles to reduce Staphylococcus aureus contamination on inanimate surfacespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FCTM%2F50025%2F2013/PT
oaire.citation.endPage11pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volume14pt_PT
oaire.fundingStream5876
person.familyNamePiçarra
person.familyNameLopes
person.familyNameMarques de Almeida
person.familyNameAires-de-Sousa
person.givenNameSusana
person.givenNameElizeth
person.givenNamePedro
person.givenNameMarta
person.identifier60599
person.identifier.ciencia-idE51A-817A-39AE
person.identifier.ciencia-id0218-71B2-2DE0
person.identifier.ciencia-idCC11-681F-CED1
person.identifier.orcid0000-0002-1567-9242
person.identifier.orcid0000-0002-9837-5155
person.identifier.orcid0000-0001-7356-8455
person.identifier.orcid0000-0001-5036-2446
person.identifier.ridE-7261-2015
person.identifier.ridB-4356-2009
person.identifier.scopus-author-id6603095288
person.identifier.scopus-author-id57190384213
person.identifier.scopus-author-id6603316273
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication79d16d6f-f8b3-43f6-ab25-1eb8efe8258d
relation.isAuthorOfPublication12cae01b-7861-4c2d-8d37-677271705baa
relation.isAuthorOfPublication429b6d71-328e-42b3-8151-15493de249b8
relation.isAuthorOfPublicationf3537080-62cc-4b0d-9e47-1a7ea3df7b63
relation.isAuthorOfPublication.latestForDiscovery429b6d71-328e-42b3-8151-15493de249b8
relation.isProjectOfPublicatione7fba2ab-23e9-40ca-a6de-695e974393e6
relation.isProjectOfPublication.latestForDiscoverye7fba2ab-23e9-40ca-a6de-695e974393e6

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Novel_PLAlmeida.pdf
Size:
1.91 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ISEL - Física - Artigos