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Methyl-cyclopentadienyl ruthenium compounds with 2,2 '-bipyridine derivatives display strong anticancer activity and multidrug resistance potential

2018-04-16Journal article Restricted access
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dc.contributor.authorCôrte-Real, Leonor
dc.contributor.authorGonçalves Teixeira, Ricardo
dc.contributor.authorGirio, Patrícia
dc.contributor.authorComsa, Elisabeta
dc.contributor.authorMORENO, Alexis
dc.contributor.authorNasr, Rachad
dc.contributor.authorBaubichon-Cortay, Helene
dc.contributor.authorAvecilla, Fernando
dc.contributor.authorMarques, Fernanda
dc.contributor.authorRobalo, Maria Paula
dc.contributor.authorMendes, Paulo
dc.contributor.authorPrates Ramalho, João P.
dc.contributor.authorGarcia
dc.contributor.authorFalson, Pierre
dc.contributor.authorValente, Andreia
dc.date.accessioned2018-12-03T13:15:35Z
dc.date.available2018-12-03T13:15:35Z
dc.date.issued2018-04-16
dc.description.abstractNew ruthenium methyl-cyclopentadienyl compounds bearing bipyridine derivatives with the general formula [Ru(eta(5)-MeCp)(PPh3)(4,4'-R-2,2'-bpy)](+) (Ru1, R = H; Ru2, R = CH3; and Ru3, R = CH2OH) have been synthesized and characterized by spectroscopic and analytical techniques. Ru1 crystallized in the monoclinic P2(1)/c, Ru2 in the triclinic P (1) over bar, and Ru3 in the monoclinic P2(1)/n space group. In all molecular structures, the ruthenium center adopts a "piano stool" distribution. Density functional theory calculations were performed for all complexes, and the results support spectroscopic data. Ru1 and Ru3 were poor substrates of the main multidrug resistance human pumps, ABCB1, ABCG2, ABCC1, and ABCC2, while Ru2 displayed inhibitory properties of ABCC1 and ABCC2 pumps. Importantly, all compounds displayed a very high cytotoxic profile for ovarian cancer cells (sensitive and resistant) that was much more pronounced than that observed with cisplatin, making them very promising anticancer agents.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCORTE-REAL, Leonor; [et al] – Methyl-cyclopentadienyl ruthenium compounds with 2,2 '-bipyridine derivatives display strong anticancer activity and multidrug resistance potential. Inorganic Chemistry. ISSN 0020-1669. Vol. 57, N.º 8 (2018), pp. 4629-4639pt_PT
dc.identifier.doi10.1021/acs.inorgchem.8b00358pt_PT
dc.identifier.issn0020-1669
dc.identifier.issn1520-510X
dc.identifier.urihttp://hdl.handle.net/10400.21/9123
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relationIF/01302/2013 - Investigator FCT Initiativept_PT
dc.relationSFRH/BD/100515/2014 - FCTpt_PT
dc.relationANR-13-BSV5-0001-01 - French National Research Agencypt_PT
dc.relation.publisherversionhttps://pubs.acs.org/doi/pdf/10.1021/acs.inorgchem.8b00358pt_PT
dc.subjectSpectroscopicpt_PT
dc.subjectMultidrug resistancept_PT
dc.subjectCytotoxic profilept_PT
dc.titleMethyl-cyclopentadienyl ruthenium compounds with 2,2 '-bipyridine derivatives display strong anticancer activity and multidrug resistance potentialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00100%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04349%2F2013/PT
oaire.citation.endPage4639pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage4629pt_PT
oaire.citation.titleInorganic Chemistrypt_PT
oaire.citation.volume57pt_PT
oaire.fundingStream5876
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person.familyNameCôrte-Real
person.familyNameGonçalves Teixeira
person.familyNameComsa
person.familyNameMORENO
person.familyNameAvecilla
person.familyNameMarujo Marques
person.familyNameRobalo
person.familyNamePrates Ramalho
person.familyNameAnselmo Viegas Garcia
person.familyNameFalson
person.familyNameValente
person.givenNameLeonor
person.givenNameRicardo
person.givenNameElisabeta
person.givenNameAlexis
person.givenNameFernando
person.givenNameFernanda
person.givenNameMaria Paula
person.givenNameJoão P.
person.givenNameMaria Helena
person.givenNamePierre
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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