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Phenolic profile and biological activities of decoctions from Santolina impressa, a Portuguese endemic species

2020-06Journal article Restricted access
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dc.contributor.authorRodrigues, Ana M.
dc.contributor.authorFale, Pedro
dc.contributor.authorMadeira, Paulo
dc.contributor.authorPacheco, Rita
dc.contributor.authorFlorêncio, Maria Helena
dc.contributor.authorAscensão, Lia
dc.contributor.authorSerralheiro, Maria Luisa
dc.date.accessioned2021-01-25T14:43:29Z
dc.date.available2021-01-25T14:43:29Z
dc.date.issued2020-06
dc.description.abstractSantolina impressa Hoffmanns & Link is an aromatic Asteraceae species endemic to the southwest of Portugal. It is used in folk medicine as an herbal tea for gastrointestinal ailments and mouthwash antiseptic. The present study aimed to relate the chemical composition of decoctions from the aerial parts S. impressa with their antiacetylcholinesterase, antioxidant, antimicrobial and cytotoxic activities, in an attempt to explain the traditional use of this species. LC–MS/MS analysis identified chlorogenic acid and cynarin as the main components. Antimicrobial activity of the extracts was investigated against two cariogenic bacteria:- Streptococcus sobrinus and Streptococcus mutans, and these decoctions were not cytotoxic towards Caco-2 and HepG2 cell lines. Decoctions from capitula and stems/leaves showed high AChE inhibition, with IC50 values of 328 μg/mL and 579 μg/mL, respectively. The antioxidant activity measured using the DPPH radical scavenging assay showed an EC50 of 14.7 μg/mL and 12.9 μg/mL for capitula and stems/leaves extracts, respectively. The biological activities were kept constant after in vitro digestive process and the HPLC analysis did not indicate changes in the extract’s chemical composition. The results may explain the traditional use of S. impressa decoctions for digestive problems and as a mouthwash antiseptic.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRODRIGUES, Ana Margarida; [et al] – Phenolic profile and biological activities of decoctions from Santolina impressa, a Portuguese endemic species. Journal of Herbal Medicine. ISSN 2210-8033. Vol. 21 (2020), pp. 1-7pt_PT
dc.identifier.eissn2210-8041
dc.identifier.issn2210-8033
dc.identifier.urihttp://hdl.handle.net/10400.21/12679
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPEst-UID/AMB/50017/2013 - FCTpt_PT
dc.relation.publisherversionhttps://reader.elsevier.com/reader/sd/pii/S2210803320300075?token=388002E8355E62DCA47194CDDAEBDA0D86AB50415E7D052A7D424B18D4E6F5FF577F39FFA74413562EBF82AD43F6B2D0pt_PT
dc.subjectAcetylcholinesterase inhibitionpt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectCell toxicitypt_PT
dc.subjectCariogenic activitypt_PT
dc.subjectChlorogenic acidpt_PT
dc.subjectCynarinpt_PT
dc.subjectSantolina impressapt_PT
dc.titlePhenolic profile and biological activities of decoctions from Santolina impressa, a Portuguese endemic speciespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FQUI%2FUI0612%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00612%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04046%2F2013/PT
oaire.citation.endPage7pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Herbal Medicinept_PT
oaire.citation.volume21pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameRodrigues
person.familyNameFale
person.familyNameMadeira
person.familyNamePacheco
person.familyNameFlorêncio
person.familyNameAscensão
person.familyNameSerralheiro
person.givenNameAna M.
person.givenNamePedro
person.givenNamePaulo
person.givenNameRita
person.givenNameMaria Helena
person.givenNameLia
person.givenNameMaria Luisa
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person.identifier.orcid0000-0001-7439-5912
person.identifier.orcid0000-0001-7541-9613
person.identifier.ridA-5570-2013
person.identifier.ridC-3062-2012
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person.identifier.scopus-author-id56589402100
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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