Repository logo
 
Publication

Bridging the gap between target-based and phenotypic-based drug discovery

2024-07-02Journal article Restricted access
Simple item page
dc.contributor.authorCalado, Cecília
dc.date.accessioned2024-11-04T09:01:08Z
dc.date.available2024-11-04T09:01:08Z
dc.date.issued2024-07-02
dc.description.abstractIntroduction: The unparalleled progress in science of the last decades has brought a better understanding of the molecular mechanisms of diseases. This promoted drug discovery processes based on a target approach. However, despite the high promises associated, a critical decrease in the number of first-in-class drugs has been observed. Areas Covered: This review analyses the challenges, advances, and opportunities associated with the main strategies of the drug discovery process, i.e. based on a rational target approach and on an empirical phenotypic approach. This review also evaluates how the gap between these two crossroads can be bridged toward a more efficient drug discovery process. Expert opinion: The critical lack of knowledge of the complex biological networks is leading to targets not relevant for the clinical context or to drugs that present undesired adverse effects. The phenotypic systems designed by considering available molecular mechanisms can mitigate these knowledge gaps. Associated with the expansion of the chemical space and other technologies, these designs can lead to more efficient drug discoveries. Technological and scientific knowledge should also be applied to identify, as early as possible, both drug targets and mechanisms of action, leading to a more efficient drug discovery pipeline.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCALADO, Cecília R. C. – Bridging the gap between target-based and phenotypic-based drug discovery. Expert Opinion on Drug Discovery. ISSN 1746-0441. Vol. 19. N.º 7 (2024), pp. 789-798.pt_PT
dc.identifier.doi10.1080/17460441.2024.2355330pt_PT
dc.identifier.issn1746-0441
dc.identifier.urihttp://hdl.handle.net/10400.21/17825
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationPTDC/ EQU-EQU/3708/2021 - Fundação para a Ciência e a Tecnologia (FCT)pt_PT
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/17460441.2024.2355330pt_PT
dc.subjectdrug discoverypt_PT
dc.subjectphenotypic assaypt_PT
dc.subjecttarget-basedpt_PT
dc.subjectcellular based assaypt_PT
dc.subjectsystems biologypt_PT
dc.titleBridging the gap between target-based and phenotypic-based drug discoverypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/DSAIPA%2FDS%2F0117%2F2020/PT
oaire.citation.endPage798pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage789pt_PT
oaire.citation.volume19pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameCalado
person.givenNameCecília
person.identifier130332
person.identifier.ciencia-id9418-E320-3177
person.identifier.orcid0000-0002-5264-9755
person.identifier.ridE-2102-2014
person.identifier.scopus-author-id6603163260
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione8577257-c64c-4481-9b2b-940fedb360cc
relation.isAuthorOfPublication.latestForDiscoverye8577257-c64c-4481-9b2b-940fedb360cc
relation.isProjectOfPublication8f80f51c-b563-49e2-9864-a2c78479fc19
relation.isProjectOfPublication.latestForDiscovery8f80f51c-b563-49e2-9864-a2c78479fc19

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Bridging the gap_CRCCalado.pdf
Size:
1.15 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ISEL - Eng. Quim. Biol. - Artigos