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Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted delivery of novel chemotherapeutic agentes

2017-01-10Journal article Restricted access
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dc.contributor.authorFernandes, Alexandra
dc.contributor.authorJesus, João
dc.contributor.authorMartins, Pedro
dc.contributor.authorFigueiredo, Sara
dc.contributor.authorRosa, Daniela
dc.contributor.authorMartins, Luisa
dc.contributor.authorCorvo, M. Luísa
dc.contributor.authorCarvalheiro, Manuela
dc.contributor.authorCosta, Pedro M.
dc.contributor.authorBaptista, Pedro
dc.date.accessioned2017-05-17T14:07:44Z
dc.date.available2017-05-17T14:07:44Z
dc.date.issued2017-01-10
dc.description.abstractDue to their small size and unique properties, multifunctional nanoparticles arise as versatile delivery systems easily grafted with a vast array of functional moieties, such as anticancer cytotoxic chemotherapeutics and targeting agents. Here, we formulated a multifunctional gold-nanoparticle (AuNP) system composed of a monoclonal antibody against epidermal growth factor receptor (EGFR) (anti-EGFR D-11) for active targeting and a Co(II) coordination compound [CoCl(H2O)(phendione)2][BF4] (phendione = 1,10-phenanthroline-5,6-dione) (TS265) with proven antiproliferative activity towards cancer cells (designated as TargetNanoTS265). The efficacy of this nanoformulation, and the non-targeted counterpart (NanoTS265), were evaluated in vitro using cancer cell models and in vivo using mice xenografts. Compared to the free compound, both nanoformulations (TargetNanoTS265 and NanoTS265) efficiently delivered the cytotoxic cargo in a controlled selective manner due to the active targeting, boosting tumor cytotoxicity. Treatment of HCT116-derived xenografts tumors with TargetNanoTS265 led to 93% tumor reduction. This simple conceptual nanoformulation demonstrates the potential of nanovectorization of chemotherapeutics via simple assembly onto AuNPs of BSA/HAS-drug conjugates that may easily be expanded to suit other cargo of novel compounds that require optimized controlled delivery to cancer target.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFERNANDES, Alexandra R.; [et al] – Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted delivery of novel chemotherapeutic agentes. Journal of Controlled Release. ISSN 0168-3659. Vol. 245 (2017), pp. 52-61pt_PT
dc.identifier.doihttps://doi.org/10.1016/j.jconrel.2016.11.021pt_PT
dc.identifier.issn0168-3659
dc.identifier.urihttp://hdl.handle.net/10400.21/7019
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttp://ac.els-cdn.com/S016836591631210X/1-s2.0-S016836591631210X-main.pdf?_tid=1acb5b88-3b08-11e7-ae52-00000aab0f6c&acdnat=1495029345_c2823ecd72eb77c3e3d3dc174193eb9bpt_PT
dc.subjectGold nanoparticlespt_PT
dc.subjectTargetingpt_PT
dc.subjectNanomedicinept_PT
dc.subjectCancer therapypt_PT
dc.subjectMetal complexespt_PT
dc.subjectColorectal cancerpt_PT
dc.subjectLung cancerpt_PT
dc.titleMultifunctional gold-nanoparticles: A nanovectorization tool for the targeted delivery of novel chemotherapeutic agentespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04378%2F2013/PT
oaire.citation.endPage61pt_PT
oaire.citation.startPage52pt_PT
oaire.citation.titleJournal of Controlled Releasept_PT
oaire.citation.volume245pt_PT
oaire.fundingStream5876
person.familyNameFernandes
person.familyNameJesus
person.familyNameMartins
person.familyNameCorvo
person.familyNameCarvalheiro
person.familyNameCosta
person.familyNameBaptista
person.givenNameAlexandra
person.givenNameJoão
person.givenNameLuisa
person.givenNameM. Luísa
person.givenNameManuela
person.givenNamePedro M.
person.givenNamePedro
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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