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Combination of chemotherapy and Au-nanoparticle photothermy in the visible light to tackle doxorubicin resistance in cancer cells

2018-07-30Journal article Open access
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dc.contributor.authorPedrosa, Pedro
dc.contributor.authorMendes, Rita
dc.contributor.authorCabral, Rita
dc.contributor.authorMartins, Luisa
dc.contributor.authorBaptista, Pedro
dc.contributor.authorFernandes, Alexandra
dc.date.accessioned2018-11-29T10:47:19Z
dc.date.available2018-11-29T10:47:19Z
dc.date.issued2018-07-30
dc.description.abstractDespite great advances in the fight against cancer, traditional chemotherapy has been hindered by the dose dependent adverse side effects that reduce the usable doses for effective therapy. This has been associated to drug resistance in tumor cells that often cause relapse and therapy failure. These drawbacks have been tackled by combining different therapeutic regiments that prevent drug resistance while decreasing the chemotherapy dose required for efficacious ablation of cancer. In fact, new metallic compounds have been in a continuous development to extend the existing chemotherapy arsenal for these combined regimens. Here, we demonstrate that combination of a metallic compound (TS265), previously characterized by our group, with photothermy circumvents cells resistant to Doxorubicin (DOX). We first engendered a colorectal carcinoma cell line (HCT116) highly resistant to DOX, whose viability was diminished after administration of TS265. Cancer cell death was potentiated by challenging these cells with 14 nm spherical gold nanoparticles followed by laser irradiation at 532 nm. The combination of TS265 with photothermy lead to 65% cell death of the DOX resistant cells without impacting healthy cells. These results support the use of combined chemotherapy and photothermy in the visible spectrum as an efficient tool for drug resistant tumors.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPEDROSA, Pedro; [et al] – Combination of chemotherapy and Au-nanoparticle photothermy in the visible light to tackle doxorubicin resistance in cancer cells. Scientific Reports. ISSN 2045-2322. Vol. 8 (2018), pp. 1-8pt_PT
dc.identifier.doi10.1038/s41598-018-29870-0pt_PT
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.21/9106
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Researchpt_PT
dc.relationPOCI-01-0145-FEDER-007728pt_PT
dc.relationA DEFINIR
dc.relationalterado para: A precision medicine platform using patient derived cancer cell models to predict drug efficacy.
dc.subjectChemotherapypt_PT
dc.subjectPhotothermypt_PT
dc.subjectDoxorubicinpt_PT
dc.subjectQuimioterapiapt_PT
dc.titleCombination of chemotherapy and Au-nanoparticle photothermy in the visible light to tackle doxorubicin resistance in cancer cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleA DEFINIR
oaire.awardTitlealterado para: A precision medicine platform using patient derived cancer cell models to predict drug efficacy.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04378%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00100%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F105734%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F132163%2F2017/PT
oaire.citation.endPage8pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume8pt_PT
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStreamOE
person.familyNamePedrosa
person.familyNameSoares Mendes
person.familyNameCabral
person.familyNameMartins
person.familyNameBaptista
person.familyNameFernandes
person.givenNamePedro
person.givenNameAna Rita
person.givenNameRita
person.givenNameLuisa
person.givenNamePedro
person.givenNameAlexandra
person.identifier758457
person.identifier637885
person.identifier464205
person.identifier.ciencia-idED1C-A943-2B18
person.identifier.ciencia-id261D-A56E-B957
person.identifier.ciencia-idE218-E297-A4EA
person.identifier.ciencia-id021D-7DC8-C92F
person.identifier.orcid0000-0002-7190-6438
person.identifier.orcid0000-0002-0672-2958
person.identifier.orcid0000-0003-2741-8100
person.identifier.orcid0000-0002-5403-9352
person.identifier.orcid0000-0001-5255-7095
person.identifier.orcid0000-0003-2054-4438
person.identifier.ridT-3862-2017
person.identifier.ridG-6210-2011
person.identifier.ridA-1237-2009
person.identifier.ridC-7465-2011
person.identifier.scopus-author-id55936173200
person.identifier.scopus-author-id36054503100
person.identifier.scopus-author-id8650947800
person.identifier.scopus-author-id8555709200
person.identifier.scopus-author-id7201782186
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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