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Targeting canine mammary tumours via gold nanoparticles functionalized with promising Co(II) and Zn(II) compounds

2017-12Journal article Restricted access
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dc.contributor.authorRaposo, L. R.
dc.contributor.authorRoma-Rodrigues, C.
dc.contributor.authorJesus, J.
dc.contributor.authorMartins, Luisa
dc.contributor.authorPombeiro, Armando
dc.contributor.authorBaptista, P. V.
dc.contributor.authorFernandes, A. R.
dc.date.accessioned2017-12-05T10:22:57Z
dc.date.available2017-12-05T10:22:57Z
dc.date.issued2017-12
dc.description.abstractBackground: Despite continuous efforts, the treatment of canine cancer has still to deliver effective strategies. For example, traditional chemotherapy with doxorubicin and/or docetaxel does not significantly increase survival in dogs with canine mammary tumors (CMTs). Aims: Evaluate the efficiency of two metal compounds [Zn(DION)2]Cl (TS262, DION = 1,10- phenanthroline-5,6-dione) and [CoCl(H2O)(DION)2][BF4] (TS265) and novel nanovectorizations designed to improve the anti-cancer efficacy of these compounds in a new CMT derived cell line (FR37-CMT). Materials and methods: FR37-CMT cells were exposed to different concentrations of TS262 and TS265 and two new nanoparticle systems and cellular viability was determined. These nanosystems are composed of polyethylene-glycol, bovine-serum-albumin and TS262 or TS265 (NanoTS262 or NanoTS265, respectively). Results: In FR37-CMT, TS262 and TS265 displayed IC50 values well below those displayed by doxorubicin and cisplatin. The nanovectorizations further decreased the IC50 values. Discussion: TS262 and TS265 proved to be effective against FR37-CMT cells and more effective than of doxorubicin and cisplatin. The Nanosystems efficiently delivered the cytotoxic cargo inducing a significant reduction of cell viability in FR37-CMT cell line when compared to the free compounds. Conclusions: TS262 and TS265 are compounds with potential in the treatment of CMTs. NanoTS262 and NanoTS265 demonstrate that such simple nanovectorization via gold nanoparticles shows tremendous potential as anti-cancer formulations, which may easily be expanded to suit other cargo.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRAPOSO, L. R.; [et al] – Targeting canine mammary tumours via gold nanoparticles functionalized with promising Co(II) and Zn(II) compounds. Veterinary and Comparative Oncology. ISSN 1476-5810. Vol. 15, N.º 4 (2017), pp. 1537-1542pt_PT
dc.identifier.doi10.1111/vco.12298pt_PT
dc.identifier.issn1476-5810
dc.identifier.issn1476-5829
dc.identifier.urihttp://hdl.handle.net/10400.21/7645
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationPOCI-01-0145-FEDER-007728pt_PT
dc.relationTRANSCRIPTOME AND PROTEOME PROFILING OF CANINE MAMMARY TUMORS: DOG AS A GENETIC MODEL FOR UNREVEALING MAMMARY CANCER MOLECULAR SIGNATURES
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/vco.12298/epdfpt_PT
dc.subjectcanine mammary tumourspt_PT
dc.subjectcisplatinpt_PT
dc.subjectdoxorubicinpt_PT
dc.subjectFR37-CMTpt_PT
dc.subjectgold nanoparticlespt_PT
dc.subjectnanotechnologypt_PT
dc.titleTargeting canine mammary tumours via gold nanoparticles functionalized with promising Co(II) and Zn(II) compoundspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTRANSCRIPTOME AND PROTEOME PROFILING OF CANINE MAMMARY TUMORS: DOG AS A GENETIC MODEL FOR UNREVEALING MAMMARY CANCER MOLECULAR SIGNATURES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04378%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F70202%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00100%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FDTP%2F04138%2F2013/PT
oaire.citation.endPage1542pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1537pt_PT
oaire.citation.titleVeterinary and Comparative Oncologypt_PT
oaire.citation.volume15pt_PT
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameMartins
person.familyNamePombeiro
person.givenNameLuisa
person.givenNameArmando
person.identifier637885
person.identifier.ciencia-idE218-E297-A4EA
person.identifier.ciencia-id8311-38FA-CEFB
person.identifier.orcid0000-0002-5403-9352
person.identifier.orcid0000-0001-8323-888X
person.identifier.ridG-6210-2011
person.identifier.ridI-5945-2012
person.identifier.scopus-author-id8650947800
person.identifier.scopus-author-id7006067269
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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