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A scope at antifouling strategies to prevent catheter-associated infections

2020Journal article Restricted access
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dc.contributor.authorFaustino, Célia M.C.
dc.contributor.authorLemos, Sara M.C.
dc.contributor.authorMonge, Nuno
dc.contributor.authorRibeiro, Isabel A.C.
dc.date.accessioned2020-08-25T09:18:13Z
dc.date.available2020-08-25T09:18:13Z
dc.date.issued2020
dc.description.abstractThe use of invasive medical devices is becoming more common nowadays, with catheters representing one of the most used medical devices. However, there is a risk of infection associated with the use of these devices, since they are made of materials that are prone to bacterial adhesion with biofilm formation, often requiring catheter removal as the only therapeutic option. Catheter-related urinary tract infections (CAUTIs) and central lineassociated bloodstream infections (CLABSIs) are among the most common causes of healthcare-associated infections (HAIs) worldwide while endotracheal intubation is responsible for ventilator-associated pneumonia (VAP). Therefore, to avoid the use of biocides due to the potential risk of bacterial resistance development, antifouling strategies aiming at the prevention of bacterial adherence and colonization of catheter surfaces represent important alternative measures. This review is focused on the main strategies that are able to modify the physical or chemical properties of biomaterials, leading to the creation of antiadhesive surfaces. The most promising approaches include coating the surfaces with hydrophilic polymers, such as poly(ethylene glycol) (PEG), poly(acrylamide) and poly(acrylates), betaine-based zwitterionic polymers and amphiphilic polymers or the use of bulk-modified poly(urethanes). Natural polysaccharides and association with polysaccharides, namely with heparin, have also been used to improve hemocompatibility. Recently developed bioinspired techniques yielding very promising results in the prevention of bacterial adhesion and colonization of surfaces include slippery liquid-infused porous surfaces (SLIPS) based on the superhydrophilic rim of the pitcher plant and the Sharklet topography inspired by the shark skin, which are potential candidates as surface-modifying approaches for biomedical devices. Concerning the potential application of most of these strategies in catheters, more in vivo studies and clinical trials are needed to assure their efficacy and safety for possible future use.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationC.M.C. Faustino, S.M.C. Lemos, N. Monge, et al., A scope at antifouling strategies to prevent catheter-associated infections, Advances in Colloid and Interface Science (2020), https://doi.org/10.1016/j.cis.2020.102230pt_PT
dc.identifier.doi10.1016/j.cis.2020.102230pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12183
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0001868620301044pt_PT
dc.subjectAdhesionpt_PT
dc.subjectAntifoulingpt_PT
dc.subjectBiofilmpt_PT
dc.subjectBiomaterialpt_PT
dc.subjectCatheterpt_PT
dc.subjectInfectionpt_PT
dc.titleA scope at antifouling strategies to prevent catheter-associated infectionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage102230pt_PT
oaire.citation.titleAdvances in Colloid and Interface Sciencept_PT
person.familyNameMonge
person.givenNameNuno
person.identifier.ciencia-id201F-6666-FB5F
person.identifier.orcid0000-0002-7306-5804
person.identifier.ridC-7789-2016
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3577de76-7e85-4139-a257-9a55cfc069b9
relation.isAuthorOfPublication.latestForDiscovery3577de76-7e85-4139-a257-9a55cfc069b9

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