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Laccases: versatile biocatalysts for the synthesis of heterocyclic cores

2021-06-18Journal article Open access
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dc.contributor.authorSousa, Ana Catarina
dc.contributor.authorMartins, Lígia O.
dc.contributor.authorRobalo, M. Paula
dc.date.accessioned2021-07-14T09:04:56Z
dc.date.available2021-07-14T09:04:56Z
dc.date.issued2021-06-18
dc.description.abstractLaccases are multicopper oxidases that have shown a great potential in various biotechnological and green chemistry processes mainly due to their high relative non-specific oxidation of phenols, arylamines and some inorganic metals, and their high redox potentials that can span from 500 to 800 mV vs. SHE. Other advantages of laccases include the use of readily available oxygen as a second substrate, the formation of water as a side-product and no requirement for cofactors. Importantly, addition of low-molecular-weight redox mediators that act as electron shuttles, promoting the oxidation of complex bulky substrates and/or of higher redox potential than the enzymes themselves, can further expand their substrate scope, in the so-called laccase-mediated systems (LMS). Laccase bioprocesses can be designed for efficiency at both acidic and basic conditions since it is known that fungal and bacterial laccases exhibit distinct optimal pH values for the similar phenolic and aromatic amines. This review covers studies on the synthesis of five- and six-membered ring heterocyclic cores, such as benzimidazoles, benzofurans, benzothiazoles, quinazoline and quinazolinone, phenazine, phenoxazine, phenoxazinone and phenothiazine derivatives. The enzymes used and the reaction protocols are briefly outlined, and the mechanistic pathways described.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSOUSA, Ana Catarina; MARTINS, Lígia O.; ROBALO, M. Paula – Laccases: versatile biocatalysts for the synthesis of heterocyclic cores. Molecules. ISSN 1420-3049. Vol. 26, N.º 12 (2021), pp. 1-26pt_PT
dc.identifier.doi10.3390/molecules26123719pt_PT
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.21/13549
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationPTDC/BBB-EBB/0122/2014 - FCTpt_PT
dc.relationUID/QUI/00100/2019 - FCTpt_PT
dc.relationUIDB/04612/2020 - Project MOSTMICRO-ITQBpt_PT
dc.relationUIDP/04612/2020 - Project MOSTMICRO-ITQBpt_PT
dc.subjectBiocatalysispt_PT
dc.subjectHeterocyclespt_PT
dc.subjectOxidoreductasespt_PT
dc.subjectBioprocessespt_PT
dc.subjectCross-coupling reactionspt_PT
dc.subjectGreen methodspt_PT
dc.subjectSustainabilitypt_PT
dc.titleLaccases: versatile biocatalysts for the synthesis of heterocyclic corespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIO%2F72108%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/RECI%2FQEQ-QIN%2F0189%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00100%2F2013/PT
oaire.citation.endPage26pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume26pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
person.familyNameSousa
person.familyNameMartins
person.familyNameRobalo
person.givenNameAna Catarina
person.givenNameLígia O.
person.givenNameMaria Paula
person.identifier319225
person.identifier.ciencia-idE81E-0596-BF29
person.identifier.ciencia-id731B-B843-C1DF
person.identifier.ciencia-idE11C-A704-9C18
person.identifier.orcid0000-0001-6133-7406
person.identifier.orcid0000-0003-0082-9591
person.identifier.orcid0000-0002-8200-6910
person.identifier.ridU-3597-2017
person.identifier.ridC-2513-2009
person.identifier.ridB-2002-2012
person.identifier.scopus-author-id7102109314
person.identifier.scopus-author-id9269662100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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