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Effect of 1,10-phenanthroline on DNA binding, DNA cleavage, cytotoxic and lactate dehydrogenase inhibition properties of Robson type macrocyclic dicopper(II) complex

2013-11-26Journal article Restricted access
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dc.contributor.authorAnbu, Sellamuthu
dc.contributor.authorKillivalavan, Asaithambi
dc.contributor.authorAlegria, Elisabete
dc.contributor.authorMathan, Ganeshan
dc.contributor.authorKandaswamy, Muthusamy
dc.date.accessioned2020-07-15T15:24:36Z
dc.date.available2020-07-15T15:24:36Z
dc.date.issued2013-11-26
dc.description.abstractDNA targeting macrocyclic dicopper(II) complex, [Cu2L(H2O)2](phen)2(ClO4)2 (L = μ-11,23-dimethyl-3,7,15,19-tetraazatricyclo-[19.3.1.19,13,21] he p t a c o s a-1(24), 2, 7, 9, 11, 13(26), 14, 19, 21(25), 22-decaene-25,26-diol) (2), has been synthesized and characterized. This has been synthesized by reacting a Robson type macrocyclic precursor dicopper(II) complex [Cu2L(H2O)2](ClO4)2 (1) and 1,10-phenanthroline in ethanol. Solution ESR, electronic, and ESI-MS spectral studies suggest that 1,10-phenanthroline replaces coordinated water in 1, giving 2. The influence of the phenanthroline on DNA binding, cleavage, and anticancer properties of 2 have been investigated. Complex 2 displays better DNA binding and cleavage than 1. The dicopper(II) complexes 1 and 2 show cytotoxicity in human cervical HeLa cancer cells, giving IC50 values of 79.41 and 15.82 μM, respectively. Antiproliferative properties of 1 and 2 were confirmed by Trypan Blue exclusive assay and lactate dehydrogenase enzyme level in HeLa cancer cell lysate and content media.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationANBU, Sellamuthu; [et al] – Effect of 1,10-phenanthroline on DNA binding, DNA cleavage, cytotoxic and lactate dehydrogenase inhibition properties of Robson type macrocyclic dicopper(II) complex. Journal of Coordination Chemistry. ISSN 0095-8972. Vol. 66, N.º 22 (2013), pp. 3989–4003pt_PT
dc.identifier.doi10.1080/00958972.2013.858136pt_PT
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.urihttp://hdl.handle.net/10400.21/12041
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relation.publisherversionhttps://www.tandfonline.com/doi/pdf/10.1080/00958972.2013.858136?needAccess=truept_PT
dc.subjectDicopper(II) complexespt_PT
dc.subjectDNA binding and cleavagept_PT
dc.subjectTrypan Blue assaypt_PT
dc.subjectAnticancer propertiespt_PT
dc.subjectLDH inhibitionpt_PT
dc.titleEffect of 1,10-phenanthroline on DNA binding, DNA cleavage, cytotoxic and lactate dehydrogenase inhibition properties of Robson type macrocyclic dicopper(II) complexpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4003pt_PT
oaire.citation.issue22pt_PT
oaire.citation.startPage3989pt_PT
oaire.citation.titleJournal of Coordination Chemistrypt_PT
oaire.citation.volume66pt_PT
person.familyNameAlegria
person.givenNameElisabete
person.identifier863202
person.identifier.ciencia-id8C1F-851A-9F1C
person.identifier.orcid0000-0003-4060-1057
person.identifier.ridE-9945-2012
person.identifier.scopus-author-id8315848300
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6d781c38-c45e-4159-b795-8c8675606160
relation.isAuthorOfPublication.latestForDiscovery6d781c38-c45e-4159-b795-8c8675606160

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