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Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications

2021-03-24Journal article Restricted access
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dc.contributor.authorFernandes, Tiago
dc.contributor.authorCosta, Inês F. M.
dc.contributor.authorJorge, Paula
dc.contributor.authorSousa, Ana Catarina
dc.contributor.authorAndré, Vânia
dc.contributor.authorCerca, N.
dc.contributor.authorKirillov, Alexander M.
dc.date.accessioned2021-10-11T12:53:26Z
dc.date.available2021-10-11T12:53:26Z
dc.date.issued2021-03-24
dc.description.abstractThis study describes a template-mediated self-assembly synthesis, full characterization, and structural features of two new silver-based bioactive coordination polymers (CPs) and their immobilization into acrylated epoxidized soybean oil (ESOA) biopolymer films for antimicrobial applications. The 3D silver(I) CPs [Ag-4(mu(8)-H(2)pma)(2)](n)center dot 4nH(2)O (1) and [Ag-5(mu(6)-H(0.5)tma)(2)(H2O)(4)] (n)center dot 2nH(2)O (2) were generated from AgNO3 and pyromellitic (H(4)pma) or trimesic (H(3)tma) acid, also using N,N'-dimethylethanolamine (Hdmea) as a template. Both 1 and 2 feature the intricate 3D layer-pillared structures driven by distinct polycarboxylate blocks. Topological analysis revealed binodal nets with the flu and tcj/hc topology in 1 and 2, respectively. These CPs were used for fabricating new hybrid materials, namely, by doping the [ESOA](n) biopolymer films with very low amounts of 1 and 2 (0.05, 0.1, and 0.5%). Their antimicrobial activity and ability to impair bacterial biofilm formation were investigated in detail against both Gram-positive (Staphylococcus epidermidis and Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria. Both silver(I) CPs and derived biopolymer films showed activity against all the tested bacteria in a concentration-dependent manner. Compound 1 exhibited a more pronounced activity, especially in preventing biofilm growth, with mean bacterial load reductions ranging from 3.7 to 4.3 log against the four bacteria (99.99% bacterial eradication). The present work thus opens up antibiofilm applications of CP-doped biopolymers, providing new perspectives and very promising results for the design of functional biomaterials.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFERNANDES, Tiago A.; [et al] – Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications. ACS Applied Materials and Interfaces. ISSN 1944-8244. Vol. 13, N.º 11 (2021), pp. 12836-12844pt_PT
dc.identifier.doi10.1021/acsami.0c19446pt_PT
dc.identifier.eissn1944-8252
dc.identifier.issn1944-8244
dc.identifier.urihttp://hdl.handle.net/10400.21/13858
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relationLISBOA-01-0145-FEDER-029697 - Portugal 2020pt_PT
dc.relationCentro de Química Estrutural
dc.relationCentro de Química Estrutural
dc.relation57/2016 - Portugal 2020pt_PT
dc.relationNot Available
dc.subjectMetal-organic frameworkspt_PT
dc.subjectSilverpt_PT
dc.subjectCrystal structurespt_PT
dc.subjectHybrid materialspt_PT
dc.subjectAntibacterial activitypt_PT
dc.subjectBiopolymerspt_PT
dc.subjectBiofilmspt_PT
dc.titleSilver(I) coordination polymers immobilized into biopolymer films for antimicrobial applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentro de Química Estrutural
oaire.awardTitleCentro de Química Estrutural
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FQUI-QIN%2F29697%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00100%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00100%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F02725%2F2018%2FCP1572%2FCT0006/PT
oaire.citation.endPage12844pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage12836pt_PT
oaire.citation.titleACS Applied Materials and Interfacespt_PT
oaire.citation.volume13pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2018
person.familyNameFernandes
person.familyNameSousa
person.familyNamede Oliveira André
person.familyNameDias Cerca
person.familyNameKirillov
person.givenNameTiago
person.givenNameAna Catarina
person.givenNameVânia Mafalda
person.givenNameNuno Miguel
person.givenNameAlexander
person.identifierA-3006-2011
person.identifierB-4231-2010
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person.identifier.ciencia-id8B1A-CCA1-E0AE
person.identifier.orcid0000-0002-3374-612X
person.identifier.orcid0000-0001-6133-7406
person.identifier.orcid0000-0001-5599-8355
person.identifier.orcid0000-0003-3365-3537
person.identifier.orcid0000-0002-2052-5280
person.identifier.ridB-6777-2013
person.identifier.ridU-3597-2017
person.identifier.ridF-8718-2014
person.identifier.scopus-author-id24449123500
person.identifier.scopus-author-id22233327400
person.identifier.scopus-author-id6507025600
person.identifier.scopus-author-id7102545395
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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