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Isogeometric analysis for fluid shear stress in cancer cells

2020-04-03Journal article Open access
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dc.contributor.authorRodrigues, José Alberto
dc.date.accessioned2020-04-08T21:10:05Z
dc.date.available2020-04-08T21:10:05Z
dc.date.issued2020-04-03
dc.descriptionEste trabalho foi financiado pelo Concurso Anual para Projetos de Investigação, Desenvolvimento, Inovação e Criação Artística (IDI&CA) 2018 do Instituto Politécnico de Lisboa. Código de referência IPL/2018/IGACFC_ISEL
dc.description.abstractThe microenvironment of the tumor is a key factor regulating tumor cell invasion and metastasis. The effects of physical factors in tumorigenesis is unclear. Shear stress, induced by liquid flow, plays a key role in proliferation, apoptosis, invasion, and metastasis of tumor cells. The mathematical models have the potential to elucidate the metastatic behavior of the cells’ membrane exposed to these microenvironment forces. Due to the shape configuration of the cancer cells, Non-uniform Rational B-splines (NURBS) lines are very adequate to define its geometric model. The Isogeometric Analysis allows a simplified transition of exact CAD models into the analysis avoiding the geometrical discontinuities of the traditional Galerkin traditional techniques. In this work, we use an isogeometric analysis to model the fluid-generated forces that tumor cells are exposed to in the vascular and tumor microenvironments, in the metastatic process. Using information provided by experimental tests in vitro, we present a suite of numerical experiments which indicate, for standard configurations, the metastatic behavior of cells exposed to such forces. The focus of this paper is strictly on geometrical sensitivities to the shear stress’ exhibition for the cell membrane, this being its innovation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRODRIGUES, José A. – Isogeometric analysis for fluid shear stress in cancer cells. Mathematical and Computational Applications. ISSN 1300-686X. Vol. 25, N.º 2 (2020), pp. 1-22pt_PT
dc.identifier.doihttps://doi.org/10.3390/mca25020019pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/11444
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationProjeto financiado no âmbito do Concurso de Projetos de Investigação, Desenvolvimento, Inovação & Criação Artística (IDI&CA) financiados pelo Instituto Politécnico de Lisboa. IPL/2018/IGACFC_ISELpt_PT
dc.subjectDarcypt_PT
dc.subjectBrinkmanpt_PT
dc.subjectIncompressiblept_PT
dc.subjectIsogeometric analysispt_PT
dc.subjectShear stresspt_PT
dc.subjectInterstitial flowpt_PT
dc.subjectCancerpt_PT
dc.subjectNURBSpt_PT
dc.titleIsogeometric analysis for fluid shear stress in cancer cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage22pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMathematical and Computational Applicationspt_PT
oaire.citation.volume25pt_PT
person.familyNameRodrigues
person.givenNameJosé Alberto
person.identifier.ciencia-id241B-90A4-D998
person.identifier.orcid0000-0001-5630-7149
person.identifier.scopus-author-id7202707426
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6743a818-d8d5-489f-829e-43391b3257cc
relation.isAuthorOfPublication.latestForDiscovery6743a818-d8d5-489f-829e-43391b3257cc

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