ESSL - Escola Superior de Saúde de Lisboa
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Percorrer ESSL - Escola Superior de Saúde de Lisboa por Domínios Científicos e Tecnológicos (FOS) "Ciências Médicas::Ciências da Saúde"
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- Association between high myopia and non-alcoholic fatty liver disease in adolescentsPublication . Guo, Ting-Han; Dong, Xing-Xuan; Li, Dan-Lin; Grzybowski, Andrzej; Lança, Carla; Qin, Yu; Zheng, Ya-Jie; Liang, Gang; Pan, Chen-WeiPurpose: To investigate the association between high myopia and non-alcoholic fatty liver disease (NAFLD) in adolescents and to explore potential metabolic mechanisms. Methods: A total of 550 freshmen from Dali University were included. Data on refractive status, questionnaires, and serum metabolomics were collected. Multivariable logistic regression was used to assess the independent association between high myopia and NAFLD. Mediation analysis was performed to explore potential mediating metabolites, and enrichment analysis was utilized to explore key metabolic pathways. Results: The prevalence of NAFLD in the study population was 11.3%. High myopia was associated with higher odds of NAFLD (OR = 2.81, 95% CI: 1.34-5.86). Mediation analysis suggested 15 metabolites as potential mediators, with L-phenylalanine (mediating effect: 23.0%) and L-leucine (mediating effect: 16.7%) showing the largest effects. Enrichment analysis revealed that these key metabolites were primarily enriched in pathways such as aromatic and branched-chain amino acid metabolism, lysine degradation, and pantothenate and CoA biosynthesis. Conclusion: High myopia was associated with increased odds of NAFLD in adolescents, and this relationship may be partially mediated by abnormalities in amino acid and energy metabolism, suggesting potential metabolic links between ocular and hepatic conditions.
- Valorising food waste using black soldier fly larvae: a One Health assessment of mycotoxin bioaccumulation and mycotoxigenic fungi under industrial-scale conditionsPublication . Oliveira, Joana; Cervantes, Renata; Pena, Pedro; Gomes, Bianca; Kosicki, Robert; Trindade, Alexandre; Murta, Daniel; Viegas, Carla; Twarużek, Magdalena; Assunção, RicardoFood waste is a major challenge for environmental sustainability and food security. Black soldier fly larvae (BSFL, Hermetia illucens) offer a sustainable solution by converting food waste into high-quality protein, aligned with One Health principles. However, concerns over bioaccumulation of contaminants, including fungi and mycotoxins, have limited the use of food waste as insect substrate. This study evaluated whether BSFL bioaccumulate mycotoxins under industrial-scale rearing conditions, using bioaccumulation factors, while also assessing contamination with fungi of mycotoxin-producing potential. To do that, approximately two tonnes of food waste were collected from restaurants in Santarém, Portugal, processed into a test substrate, along with the cereal-based Gainesville diet as a control. Larvae were reared for 14 days, and samples of substrates, larvae, frass, and BSF meal were analysed for fungal contamination and mycotoxin concentration using culture-based methods and liquid chromatography-tandem mass spectrometry, respectively. Mycotoxigenic fungi belonging to Fusarium, Aspergillus, and Penicillium were predominantly below the limit of detection in larvae. Deoxynivalenol (DON), zearalenone (ZEN), and HT-2 toxin were detected in the substrates, but none of these mycotoxins were detected or quantified in larvae, with bioaccumulation factors consistently below one, indicating no significant accumulation. DON and ZEN were also detected in frass, in some cases at higher concentrations than in the corresponding initial substrates. These findings demonstrate that, under the conditions tested, BSFL did not bioaccumulate the mycotoxins detected in the rearing substrates, while their occurrence in frass highlights the importance of considering contaminant distribution across outputs of the bioconversion process. Overall, this study supports the safe use of BSFL for industrial-scale food waste valorisation and highlights their contribution to improving public health.