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Browsing by Author "Oliveira, S. M."

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  • Alternative regimens for prostate cancer treatment using radiation therapy
    Publication . Oliveira, S. M.; Teixeira, Nuno; Fernandes, Lisete; Brás, S.; Serra, F.
    Purpose/Objective: The purpose of this work was to determine biologically equivalent alternative regimens for the treatment of prostate cancer using External Beam Radiotherapy (EBRT) and Low Dose-Rate Brachytherapy (LDRBT) with 125I implants and to evaluate the sensitivity of these regimens to different sets of radiobiological parameters of the Linear-Quadratic (LQ) model.
    2012-05Conference object Open access Show more
  • What do we know about the α/β for prostate cancer?
    Publication . Oliveira, S. M.; Teixeira, Nuno; Fernandes, Lisete
    Since last decade, the debate on the parameter which reflects prostate cancer sensitivity to fractionation in a radiotherapy treatment, the α/β, has become extensive. Unlike most tumors, the low labeling indices (LI) and large potential doubling time that characterize the prostate tumor led some authors to consider that it may behave as a late responding tissue. So far, the existing studies with regard to this subject point to a low value of α/β, around 2.7 Gy, which may be considered as a therapeutic gain in relation to surrounding normal tissues by using fewer and larger fractions. The aim of this paper is to review several estimates that have been made in the last few years regarding the prostate cancer α/β both from clinical and experimental data, as well as the set of factors that have potentially influenced these evaluations.
    2012-06Journal article Open access Show more