Browsing by Author "Fialho, L."
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- Dual-loaded chitosan-based nanoparticles: a novel approach for treating polymicrobial osteomyelitisPublication . Zegre, Miguel; Barros, J.; David, A. B.; Fialho, L.; Ferraz, M. P.; Monteiro, F. J.; Caetano, Liliana Aranha; Gonçalves, L.; Bettencourt, A.Developing innovative approaches to target osteomyelitis caused by polymicrobial infections remains a significant therapeutic challenge. In this study, monodispersed chitosan nanoparticles co-loaded with antibacterial (minocycline) and antifungal (voriconazole) agents were successfully prepared. Minocycline presented higher encapsulation efficiency as compared to voriconazole. Thermostability analysis suggested interactions between the co-loaded drugs within the dual-delivery system, potentially limiting voriconazole release. The dual-loaded chitosan nanoparticles exhibited significant in vitro anti-biofilm activity, achieving up to a 90% reduction in polymicrobial biofilms of S. aureus and C. albicans. Additionally, the nanoparticles showed cytocompatibility with a human osteoblast cell line. These findings highlight the potential of this dual-delivery chitosan-based nanoparticle system to address a critical gap in osteomyelitis treatment by targeting both bacterial and fungal pathogens.
- PV system modeling by five parameters and in Situ testPublication . Fialho, L.; Melício, Rui; Mendes, VictorThis paper focuses on a novel formalization for assessing the five parameter modeling of a photovoltaic cell. An optimization procedure is used as a feasibility problem to find the parameters tuned at the open circuit, maximum power, and short circuit points in order to assess the data needed for plotting the I-V curve. A comparison with experimental results is presented for two monocrystalline PV modules.
- PV system modeling by five parameters and in situ testPublication . Fialho, L.; Melício, Rui; Mendes, VictorThis paper focuses on a novel formalization for assessing the five parameter modeling of a photovoltaic cell. An optimization procedure is used as a feasibility problem to find the parameters tuned at the open circuit, maximum power, and short circuit points in order to assess the data needed for plotting the I-V curve. A comparison with experimental results is presented for two monocrystalline PV modules.
- A simulation of integrated photovoltaic conversion into electric gridPublication . Fialho, L.; Melício, Rui; Mendes, Victor; Viana, S.; Rodrigues, C.; Estanqueiro, A.This paper presents a systemic modeling for a PV system integrated into an electric grid. The modeling includes models for a DC-DC boost converter and a DC-AC two-level inverter. Classical or fuzzy PI controllers with pulse width modulation by space vector modulation associated with sliding mode control is used for controlling the PV system and power factor control is introduced at the output of the system. Comprehensive performance simulation studies are carried out with the modeling of the DC-DC boost converter followed by a two-level power inverter in order to compare the performance with the experimental results obtained during in situ operation with three commercial inverters. Also, studies are carried out to assess the quality of the energy injected into the electric grid in terms of harmonic distortion. Finally, conclusions regarding the integration of the PV system into the electric grid are presented. (C) 2014 Elsevier Ltd. All rights reserved.