Percorrer por autor "Antunes, F."
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- Addressing critical fungal pathogens under a One Health perspective: key insights from the Portuguese Association of Medical MycologyPublication . Sabino, Raquel; Antunes, F.; Araujo, Ricardo; Bezerra, Ana Rita; Brandão, João; Carneiro, C.; Carvalho, Agostinho; Carvalho, D.; Conceição, I. C.; Medeiros, F. Cota; Cruz, C.; Duarte, E.; Holum, Stephanie; Matos, O.; Maltez, Fernando; Mendonça, Alexandre; Moura, Gabriela; Pereira, A.; Rodrigues, Célia Fortuna; Teixeira, P.; Valdoleiros, S. R.; Veríssimo, C.; Viegas, CarlaFungal infections have emerged as a significant public health concern, especially with the increasing incidence of severe mycoses caused by pathogens such as Aspergillus fumigatus, Candida auris, Candida albicans, and Cryptococcus neoformans. These fungi, listed as critical priorities by the World Health Organization, pose a heightened risk due to the rising prevalence of antifungal resistance and their severe impact on immunocompromised individuals. This article, coordinated by the Portuguese Association of Medical Mycology, emphasizes the importance of adopting a One Health approach to comprehensively address fungal threats. Drawing on interdisciplinary collaboration, the association aims to foster greater awareness, improve diagnostic capabilities, and stimulate research and public health policies in Portugal, but also at the global level. The paper outlines key strategies for surveillance, prevention, and innovation in fungal diagnostics and therapeutics. Moreover, it emphasizes the urgent need for national coordination and international cooperation in managing fungal infections, advocating for integrative approaches that link human, animal, and environmental health. By presenting a consolidated overview of current challenges and future priorities, this work seeks to enhance preparedness and response mechanisms in the face of escalating fungal threats.
- Hydrogen peroxide as a key player in bystander effectsPublication . Pinto, V.; Carmona, Bruno; Antunes, F.; Marinho, H. Susana; Vieira, Lina Oliveira; Soares, Helena
- Noncoding RNAs as critical players in regulatory accuracy, redox signaling, and immune cell functionsPublication . Gomes, Anita Quintal; Real, C.; Antunes, F.; Marinho, H. Susana; Nolasco, Sofia; Soares, HelenaThe transcriptome of multicellular organisms is much more complex than initially thought because it includes a large number of noncoding RNAs (ncRNAs). Data regarding ncRNAs suggest that organism complexity better correlates with the percentage of each genome that is transcribed into these molecules. The most studied classes of ncRNAs are short interfering RNAs, microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), and long noncoding RNAs (lncRNAs). In this chapter, we review the biogenesis pathways and general functions of miRNAs, piRNAs, and lncRNAs. We focus on the roles of miRNAs and lncRNAs in gene expression regulation, centering on redox signaling and immune cell development, and highlight some implications for human pathologies. Finally, we analyze current knowledge concerning the use of ncRNAs in diagnosis, prognosis, and therapeutics, and discuss their role in the development of the immune system and the regulatory functions of H2O2 during the course of metazoan evolution.