Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/3052
Título: Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease
Autor: Guerreiro, Catarina Sousa
Ferreira, Paula
Tavares, Lourdes
Santos, Paula Moura dos
Neves, Manuela
Brito, Miguel
Cravo, Marília
Palavras-chave: Crohn disease
Dietary fats
Fatty acids
Genetic predisposition to disease
Polymorphism, Single nucleotide
Risk factor
Tumor necrosis factor-alpha
Data: Set-2009
Editora: Nature
Citação: Guerreiro CS, Ferreira P, Tavares L, Santos PM, Neves M, Brito M, et al. Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease. Am J Gastroenterol. 2009;104(9):2241-9.
Resumo: Objectives - The aim of this work was to study the interaction between genetic polymorphisms (single-nucleotide polymorphisms, SNPs) of pro- and anti-inflammatory cytokines and fat intake on the risk of developing Crohn's disease (CD) or modifying disease activity. Methods - Seven SNPs in interleukin 1 (IL1), tumor necrosis factor alpha (TNFalpha), lymphotoxin alpha (LTalpha), and IL6 genes were analyzed in 116 controls and 99 patients with CD. The type of fat intake was evaluated, and the interaction between SNPs and dietary fat in modulating disease activity was analyzed. Results - Individuals who were homozygous for the IL6-174G/C polymorphism had a six-fold higher risk for CD (odds ratio (OR)=6.1; 95% confidence interval (95% CI)=1.9-19.4), whereas the TT genotype on the TNFalpha-857C/T polymorphism was associated with more active disease (OR=10.4; 95% CI=1.1-94.1). A high intake of total, saturated, and monounsaturated fats, as well as a higher ratio of n-6/n-3 polyunsaturated fatty acid (PUFA), was associated with a more active phenotype (P<0.05). Furthermore, there was an interaction between dietary fat intake and SNPs, with a high intake of saturated and monounsaturated fats being associated with active disease, mainly in patients carrying the variant alleles of the 857 TNFalpha polymorphism (OR=6.0, 95% CI=1.4-26.2; OR=5.17; 95% CI=1.4-19.2, respectively) and the 174 IL6 polymorphism (OR=2.95; 95% CI=1.0-9.1; OR=3.21; 95% CI=1.0-10.4, respectively). Finally, low intake of n-3 PUFA and high n-6/n-3 PUFA ratio in patients with the TNFalpha 857 polymorphism were associated with higher disease activity (OR=3.6; 95% CI=1.0-13.0; OR=5.92; 95% CI=1.3-26.5, respectively). Conclusions - These results show that different types of fat may interact with cytokine genotype, modulating disease activity.
Peer review: yes
URI: http://hdl.handle.net/10400.21/3052
ISSN: 1572-0241
Versão do Editor: http://www.nature.com/ajg/journal/v104/n9/full/ajg2009313a.html
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