Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/2879
Título: CCTα
Autor: Soares, Helena
Nolasco, Sofia
Palavras-chave: Gene function
Molecular medicine
Cytokines and growth factors
Cell biology
Protein-ligand interactions
Data: 2012
Editora: Springer
Citação: Soares H, Nolasco S, Gonçalves J. CCTα. In Choi S, editor. Encyclopedia of signaling molecules. New York: Springer; 2012. p. 282-8.
Resumo: In the cell, the correct folding of many proteins depends on the function of preexisting ones known as Molecular Chaperones (for a review see Hartl and Hayer-Hartl 2009). These, were defined as proteins that bind to and stabilize an otherwise unstable conformation of another protein, and by controlling binding and release, facilitate its correct fate in vivo, be it folding, oligomeric assembly, transport to a particular subcellular compartment, or disposal by degradation. Molecular chaperones do not convey steric information specifying correct folding: instead, they prevent incorrect interactions within and between nonnative peptides, thus typically increasing the yield but not the rate of folding reactions. Molecular chaperones are ubiquitous and comprise several protein families that are structurally unrelated (Hartl and Hayer-Hartl 2009). The Hsp70s and the Chaperonin families have been extensively studied.
Peer review: yes
URI: http://hdl.handle.net/10400.21/2879
ISBN: 978-1-4419-0461-4
Versão do Editor: http://rd.springer.com/referenceworkentry/10.1007%2F978-1-4419-0461-4_550#
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