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Detection of Helicobacter pylori in extragastric tissues: association of infection with carcinogenesis

2018-01Conference object Open access
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dc.contributor.authorFaria, L. M.
dc.contributor.authorAlmeida, M. S.
dc.contributor.authorAmaral, M. R.
dc.contributor.authorMarques-Ramos, Ana
dc.date.accessioned2018-06-12T11:45:47Z
dc.date.available2018-06-12T11:45:47Z
dc.date.issued2018-01
dc.description.abstractIntroduction: Helicobacter pylori (HP) is a gram-negative microaerophilic bacterium that has been described as the main pathogen of several benign and malignant diseases of the digestive tract, such as gastric and duodenal ulcers, chronic gastritis, hepatobiliary diseases, gastric lymphoma, and carcinoma. HP was classified as class I human carcinogen in 1994. The relationship between HP infection and extragastric diseases has been investigated over the years with contradictory conclusions. The objective of this work is to perform a bibliographic review on the association between HP infection and the development of extragastric pathologies, particularly of pancreatic carcinoma. It is also intended to determine the best method for the detection of the bacterium. Materials and methods: work was based on the literature from the following databases: b-on, PubMed, SciELO, Wiley Online Library and Scientific Repository of the Polytechnic Institute of Lisbon, under the terms “Helicobacter spp.”, “Helicobacter pylori”, “pancreatic cancer”, “extragastric diseases”, “risk of pancreatic cancer” and “CagA”. From a total of 32 analyzed articles, 18 were selected, excluding those with dubious methods and results that were not performed in human samples and meta-analysis. Results: In the selected studies the presence of HP DNA was detected by Polymerase Chain Reaction (PCR) in more than 50% of the pancreatic and hepatocellular cancer samples. There was also an association between the presence of this bacterium and colonic cancer, primary sclerosing cholangitis, primary biliary cirrhosis, cholecystitis and biliary tract carcinoma. However, detection by enzyme-linked immunosorbent assay provided ambiguous results, with 2 of the studies showing no association between infection and pancreatic cancer, while others showed positive results below 50%. There are also 3 studies that related the seroconversion of cytotoxin-associated gene A negative to pancreatic carcinoma. Other methods like histochemical and immunocytochemistry (ICQ) techniques were compared to each other and the results demonstrated that ICQ had the greatest consistency. Conclusions: The majority of the studies demonstrated an association between HP infection and the development of extragastric diseases. Therefore, HP is a potential risk factor for the etiology of these pathologies. Comparing previous methods, it was possible to observe that PCR was the most sensitive and specific technique for HP detection.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFaria LM, Almeida MS, Amaral MR, Marques-Ramos A. Detection of Helicobacter pylori in extragastric tissues: association of infection with carcinogenesis. In: CIMAGO Scientific Meeting, Faculty of Medicine, University of Coimbra (Portugal), January 25-26, 2018. Poster 38. Pulmonol. 2018;24(Esp Cong 1):18.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/8624
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttp://meeting.acimago.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectHelycobacter pyloript_PT
dc.subjectCarcinogenesispt_PT
dc.subjectExtragastric pathologypt_PT
dc.titleDetection of Helicobacter pylori in extragastric tissues: association of infection with carcinogenesispt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage10pt_PT
oaire.citation.startPage10pt_PT
oaire.citation.titlePulmonologypt_PT
oaire.citation.volume24pt_PT
person.familyNameMarques-Ramos
person.givenNameAna
person.identifier.ciencia-id0617-3550-881E
person.identifier.orcid0000-0003-2655-8806
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication0b8d516d-bf23-4db0-8224-d33e28d309ac
relation.isAuthorOfPublication.latestForDiscovery0b8d516d-bf23-4db0-8224-d33e28d309ac

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