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Glucose homeostasis in obese women is not associated to unacylated ghrelin plasma levels

2020-06Journal article Open access
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dc.contributor.authorVeiga, Luisa
dc.contributor.authorBrito, Miguel
dc.contributor.authorSilva, Carina
dc.contributor.authorSilva-Nunes, José
dc.date.accessioned2020-06-19T18:50:16Z
dc.date.available2020-06-19T18:50:16Z
dc.date.issued2020-06
dc.description.abstractIntroduction: Unacylated ghrelin (UAG) is the major form of circulating ghrelin. Initially considered as a nonfunctional peptide, soon after, UAG has been associated with an insulin-sensitizing action and to negative action on energy balance. The aim of this study was to analyze the association between the serum levels of UAG and glucose metabolism parameters in obese women, independently from the eventual influence of anthropometrics. Methods: One hundred lean and 254 obese Caucasian women were studied. Each woman was characterized by anthropometrics, fasting glucose, insulin, HbA1c, and UAG. In addition, obese women were subjected to a classic oral glucose tolerance test (oGTT) to assess glucose and insulin at 120 minutes. Insulin resistance was assessed by the homeostasis model assessment (HOMA-IR). Obese women were classified into three glycemic status subgroups (normoglycemia, prediabetes, and diabetes) according to HbA1c and fasting, and oGTT glucose values. Results: In comparison with the lean group, significantly lower levels of UAG were observed in obese women. However, no significant difference was observed through obesity classes I to III. UAG levels were not significantly different among glycemic status subgroups and did not show any association with glucose, insulin, HOMA-IR, or HbA1c. Conclusions: Although anthropometry can influence the level of the unacylated form of ghrelin, UAG plasma levels do not associate with glucose homeostasis parameters.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVeiga L, Brito M, Silva C, Silva-Nunes J. Glucose homeostasis in obese women is not associated to unacylated ghrelin plasma levels. Biomark Insights. 2020;15:1177271920928923.pt_PT
dc.identifier.doi10.1177/1177271920928923pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/11903
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSAGE Publicationspt_PT
dc.relation.publisherversionhttps://journals.sagepub.com/doi/full/10.1177/1177271920928923pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectUnacylated ghrelinpt_PT
dc.subjectDysglycemiapt_PT
dc.subjectInsulin resistancept_PT
dc.subjectObesitypt_PT
dc.titleGlucose homeostasis in obese women is not associated to unacylated ghrelin plasma levelspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage117727192092892pt_PT
oaire.citation.titleBiomarker Insightspt_PT
oaire.citation.volume15pt_PT
person.familyNameVeiga
person.familyNameBrito
person.familyNameSilva
person.givenNameLuisa
person.givenNameMiguel
person.givenNameCarina
person.identifier.ciencia-id9413-918D-DB0E
person.identifier.ciencia-id231F-F341-7E93
person.identifier.ciencia-id2411-5936-0820
person.identifier.orcid0000-0003-1153-8343
person.identifier.orcid0000-0001-6394-658X
person.identifier.orcid0000-0003-1021-7935
person.identifier.ridL-2730-2013
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id8318978600
person.identifier.scopus-author-id35224551000
person.identifier.scopus-author-id55258764900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationaac1914a-275f-4be2-819d-ab41d356b45a
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication81a5cd80-1982-43ba-bde5-4c43ae0e5234
relation.isAuthorOfPublication.latestForDiscovery81a5cd80-1982-43ba-bde5-4c43ae0e5234

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