Nunes, NelsonElvas Leitao, RubenMartins, Filomena2024-11-062024-11-062024-01-02Nunes, N.; Elvas-Leitão, R.; Martins, F. Study of the Ternary Mixture of Methanol/Formamide/Acetonitrile via Solvatochromic Probes. Molecules 2024, 29(1), 246. https://doi.org/10.3390/molecules29010246http://hdl.handle.net/10400.21/17850Following previous studies, the ternary mixture of methanol/formamide/acetonitrile (MeOH/Formamide/MeCN) was studied using the UV-Vis absorption spectra at 298.15 K with a set of five probes, 4-nitroaniline, 4-nitroanisole, 4-nitrophenol, N,N-dimethyl-4-nitroaniline and 2,6-diphenyl-4-(2,4,6-triphenyl-1-pyridinio)phenolate (Reichardt betaine dye), for a total of 22 mole ternary fractions. In addition, nine mole fractions of the underling binary mixtures, MeOH/Formamide and Formamide/MeCN were also tested. Spectroscopic results were used to model the preferential solvation order for each probe in the mixtures. The Kamlet–Taft solvatochromic solvent parameters, α, β, and π*, were also computed through the use of the solvatochromic shifts of the five probe indicators. Moreover, discrepancies in the spectroscopic behavior of 4-nitrophenol in formamide-rich mixtures were observed and analyzed.engTernary mixtureMethanolFormamideAcetonitrileSolvatochromic probesKamlet–Taft parametersSolvationjournal article10.3390/molecules290102461420-3049