Zegre, MiguelBastron, S.Ribeiro, I. A.Caetano, Liliana AranhaGonçalves, L.Bettencourt, A.2022-12-092022-12-092022-11Zegre M, Bastron S, Ribeiro IA, Caetano LA, Gonçalves L, Bettencourt A. Chitosan nanoparticles loaded with minocycline targeting osteomyelitis. In: Simposio Iberoamericano COIFFA-2022 [online], Mexico, November 18-19, 2022.http://hdl.handle.net/10400.21/15136Effective control of osteomyelitis (bone infection) with reduced toxicity is a current challenge. Targeted and controlled drug delivery systems allow: decreased toxicity, upgraded drug targeting, and improved therapeutic effect. Strategy: a) Innovative chitosan nanoparticulate system: nanoparticles loaded with minocycline (antibacterial), and alternative as a local delivery system; b) Nanoparticles and biofilms: advantages: enhanced bioavailability, targeted delivery of antibiotics magnification, local release of antibiotics, controlled and sustained release, and protection against deactivating enzymes.engOsteomyelitisChitosanNanoparticlesconference object