Arteiro, José Maria SantosMartins, Maria do RosárioSalvador, CátiaCandeias, Maria de FátimaKarmali, AminCaldeira, A. Teresa2015-09-082015-09-082012-06ARTEIRO, J. M. S.; [et al] – Protein-Polysaccharides of trametes versocolor: production and biological activities. Medicinal Chemistry Research. ISSN: 1054-2523. Vol. 21, nr. 6 (2012), pp. 937-9431054-2523http://hdl.handle.net/10400.21/5117Extracellular-(E-PPS) and intracellular-protein-polysaccharides (I-PPS) complexes were produced by Trametes versicolor in submerged cultures with different carbon sources. The highest extracellular-(EPS) and intracellular-polysaccharide (IPS) concentration in the complexes was obtained with tomato pomace culture. DPPH radical scavenging for E-PPS and I-PPS produced by liter of culture was equivallent to 2.115 +/- A 0.227 and 1.374 +/- A 0.364 g of ascorbic acid, respectively. These complexes showed a protector effect in the oxidation of erythrocyte membranes and had ability to inhibit the hemolysis and methemoglobin synthesis in stressed erythrocytes. These results suggest that extracellular- and intracellular- polysaccharides produced are important bioactive compounds with medicinal potential.engProtein-PolysaccharidesTrametes VersicolorSubmerged FermentationEdible MushroomsAntioxidant PropertiesActivityCoriolus-versicolorExopolysaccharide productionMetabolite productionOptimizationMorphologyMushroomsjournal article10.1007/s00044-011-9604-6