Arteiro, José Maria SantosMartins, Maria do RosárioSalvador, CátiaCandeias, M. FátimaKarmali, AminCaldeira, A. Teresa2012-11-132012-11-132012-06Arteiro J M S, Martins M R, Salvador C, Candeias M F, Karmali A, Caldeira T. Protein-polysaccharides of Trametes versicolor: production and biological activities. Medicinal Chemistry Research. 2012; 6 (21): 937-943.1054-2523http://hdl.handle.net/10400.21/1919Extracellular- (E-PPS) and intracellular-protein-polysaccharides (I-PPS) complexes were produced by Trametes versicolor in submerged cultures with different carbon sources. The highest extracellular-(EPS) and intracellular-polysaccharide (IPS) concentration in the complexes was obtained with tomato pomace culture. DPPH radical scavenging for E-PPS and I-PPS produced by liter of culture was equivallent to 2.115 +/- A 0.227 and 1.374 +/- A 0.364 g of ascorbic acid, respectively. These complexes showed a protector effect in the oxidation of erythrocyte membranes and had ability to inhibit the hemolysis and methemoglobin synthesis in stressed erythrocytes. These results suggest that extracellular- and intracellular- polysaccharides produced are important bioactive compounds with medicinal potential.engProtein-polysaccharidesTrametes versicolorEdible mushroomsSubmerged-cultureAntioxidant activityActivityCoriolus-versicolorExopolysaccharide productionMetabolite productionOptimizationMorphologyMushroomsjournal article