An enzymatic route to a benzocarbazole framework using bacterial CotA laccase

Sousa, Ana CatarinaPiedade, Maria de Fátima M. M.Martins, Lígia O.Robalo, Maria Paula2016-03-092016-03-092015SOUSA, Ana Catarina; [et al.] - An enzymatic route to a benzocarbazole framework using bacterial CotA laccase. Green Chemistry. ISSN. 1463-9262. Vol. 17, N.º 3 (2015), pp. 1429-14331463-92621463-9270http://hdl.handle.net/10400.21/5814The CotA laccase-catalysed oxidation of the meta, para-disubstituted arylamine 2,4-diaminophenyldiamine delivers, under mild reaction conditions, a benzocarbazole derivative (1) (74% yield), a key structural motif of a diverse range of applications. This work extends the scope of aromatic frameworks obtained using these enzymes and represents a new efficient and clean method to construct in one step C-C and C-N bonds.engActive carbazole alkaloidsTransition-Metal-ComplexesOrganic-SynthesisFungal laccasesAntimicrobial activityBiological evaluationCoupling reactionsBacillus-subtilisDomino reactionsGreen chemistryAn enzymatic route to a benzocarbazole framework using bacterial CotA laccasejournal article10.1039/c4gc02511c