Tarn, JessicaPinto, Ines FigueiredoNg, Wan-FaiStaats, P. S.Ayata, C.Abd-Elsayed, A.2025-03-032025-03-032025Tarn J, Pinto IF, Ng WF. Vagus nerve stimulation for the management of immune-mediated inflammatory diseases. In: Staats PS, Ayata C, Abd-Elsayed A, editors. Vagus nerve stimulation. Academic Press; 2025. p. 275-86.9780128169964http://hdl.handle.net/10400.21/21626The vagus nerve is a key component of several homeostatic axes including the cholinergic antiinflammatory pathway, hypothalamic–pituitary-adrenergic axis, and the brain-gut axis, all of which play important roles in the regulation of the immune system. Autonomic dysfunction has been described in many immune-mediated inflammatory diseases (IMIDs). In addition, several pilot studies have shown that vagus nerve stimulation leads to improvement in several IMIDs. Taken together, the vagus nerve is a promising novel therapeutic target for the management of IMIDs.engImmunemediated inflammatory diseasesVagus nerveAutonomic nervous systemCholinergic antiinflammatoryHypothalamic–pituitary-adrenalBrain-gutInflammatory bowel diseasePrimary Sjogren’s syndromeSclerodermaSystemic lupus erythematosusbook part10.1016/b978-0-12-816996-4.00026-5