Gomes, Anita Q.Martins, Duarte S.Silva-Santos, Bruno2020-08-262020-08-262010-12Gomes AQ, Martins DS, Silva-Santos B. Targeting gd T lymphocytes for cancer immunotherapy: from novel mechanistic insight to clinical application. Cancer Res. 2010;70(24):10024-7.http://hdl.handle.net/10400.21/12195Abundant interferon-γ secretion, potent cytotoxicity, and major histocompatibility complex-independent targeting of a large spectrum of tumors make γδ T cells attractive mediators of cancer immunotherapy. However, a better understanding of the molecular mechanisms involved in tumor cell recognition and γδ T-cell activation is required to improve the limited success of γδ T-cell-mediated treatments. Here, we review key advances in basic knowledge made over the past 3 years and summarize the results of γδ T-cell-based clinical trials concluded to date. We also highlight new research directions on the basis of the modulation of receptors that control the function of γδ T cells.engHumansImmunotherapy, AdoptiveLymphocyte activationNeoplasmsReceptors, AntigenT-CellGamma-deltaT-Lymphocyte subsetsjournal article10.1158/0008-5472.CAN-10-3236