Zaidi, HichamOuchemoukh, SalimAmessis-Ouchemoukh, NadiaDEBBACHE-BENAIDA, NADJETPacheco, RitaSerralheiro, Maria LuisaAraujo, Maria Eduarda2019-02-082019-02-082019-01ZAIDI, Hicham; [et al] – Biological properties of phenolic compound extracts in selected Algerian honeys-The inhibition of acetylcholinesterase and alpha-glucosidase activities. European Journal of Integrative Medicine. ISSN 1876-3820. Vol. 25, (2019), pp. 77-841876-38201876-3839http://hdl.handle.net/10400.21/9474Introduction: Honey is used in various cultures as a traditional medicine and folkloric treatment. The aim of this study was to determine the antioxidant and the anti-inflammatory activities of 31 Algerian honeys and acetylcholinesterase (AChE) and alpha-glucosidase inhibitory activities of phenolic compounds extracts of these honeys. Methods: The anti-inflammatory activity of honey was evaluated by the method of inhibition of BSA (Bovin Serum Albumin) heat-induced denaturation. The inhibition of AChE and alpha-glucosidase by the honey extracts was evaluated by in-vitro methods. Results: The highest percentage of inhibition (85.33%) of BSA denaturation was obtained with polyfloral honey (H27). Radical scavenging activity of honey samples against 1,1-diphenyl-2-picrilhydrazyl (DPPH), and 2,2'-azinobis(-3) -ethylbenzothiazoline-6-sulfonic acid (ABTS) varied from 4.41 to 83.93% and from 2.52 to 63.24%, respectively. AChE inhibitory activity is one target to prevent neurodegenerative damage in Alzheimer's disease. AChE inhibition recorded values from 20.69 to 76.04%. alpha-glucosidase inhibitors such as acarbose is preconized for the control of hyperglycemia and prevent diabetes damages. Honey extracts demonstrated a significant inhibitory effect on alpha-glucosidase activity. Moreover, the effect of Fabacece honey (H19) (IC50 = 52.20 mu g/mL) was found to be more potent than acarbose (IC50 = 204.27 mu g/mL). Correlations were observed between antioxidants and anti-inflammatory activities, AChE and alpha-glucosidase inhibitions with total phenolic compounds and flavonoids content in honey samples. Conclusion: This study showed that honey could be exploited as a potential antioxidant and anti-inflammatory agent within therapeutic medicine.engAlgerian honeysAnti-inflammatory activityAntioxidant activityAcetylcholinesterase inhibitionAlpha-Glucosidase inhibitionPhenolic compoundsjournal article10.1016/j.eujim.2018.11.008