Teixeira, Ricardo G.Brás, Ana RitaCôrte-Real, LeonorTatikonda, RajendhraprasadSanches, AnabelaRobalo, Maria PaulaAvecilla, FernandoMoreira, TiagoGarcia, M. HelenaHaukka, MattiPreto, AnaValente, Andreia2018-12-112018-12-112018-01-01TEIXEIRA, Ricardo G.; [et al] – Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells. European Journal of Medicinal Chemistry. ISSN 0223-5234. Vol. 143, (2018), pp. 503-5140223-52341768-3254http://hdl.handle.net/10400.21/9156Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(eta(5)-MeCp)(PPh3)(2)Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P (1) over bar. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(eta(5)-MeCp)(PPh3)(L1)] [CF3SO3] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4-6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent. (C) 2017 Elsevier Masson SAS. All rights reserved.engRuthenium methylcyclopentadienylColorectal cancerApoptosisCompostos organometálicosApoptoseCancro colo-retaljournal article10.1016/j.ejmech.2017.11.059