Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/645
Título: Lifestyle factors influence in the frequency in buccal micronucleus
Autor: Ladeira, Carina
Gomes, Manuel C.
Brito, Miguel
Palavras-chave: Anatomia patológica
Cancro oral
Factor de risco
Consumo de álcool
Data: Jun-2011
Citação: Ladeira C, Gomes MC, Brito M. Lifestyle factors influence in the frequency in buccal micronucleus. In 21st Meeting of the European Association for Cancer Research, Oslo (Norway), 26th to 29th June 2011. Poster.
Resumo: Genomic damage is probably the most important fundamental cause of development and degenerative disease. It is also well established that genomic damage is produced by environmental exposure to genotoxins, medical procedures (e.g. radiation and chemicals), micronutrient deficiency (e.g. folate), lifestyle factors (e.g. alcohol, smoking, drugs and stress), and genetic factors such as inherited defects in DNA metabolism and/or repair. Tobacco smoke has been associated to a higher risk of development of cancer, especially in the oral cavity, larynx and lungs, as these are places of direct contact with many carcinogenic tobacco’s compounds. Alcohol is definitely a recognized agent that influence cells in a genotoxic form, been citied as a strong agent with potential in the development of carcinogenic lesions. Epidemiological evidence points to a strong synergistic effect between cigarette smoking and alcohol consumption in the induction of cancers in the oral cavity. Approximately 90% of human cancers originate from epithelial cells. Therefore, it could be argued that oral epithelial cells represent a preferred target site for early genotoxic events induced by carcinogenic agents entering the body via inhalation and ingestion. The MN assay in buccal cells was also used to study cancerous and precancerous lesions and to monitor the effects of a number of chemopreventive agents.
Peer review: yes
URI: http://hdl.handle.net/10400.21/645
Aparece nas colecções:ESTeSL - Posters

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