Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/5339
Título: Implementation of a new reference values database for semiquantification in123I-FP-CIT brain single emission tomography
Autor: Queiroga, Margarida
Silva, Diana
Elias, Madalena
Serrano, José
Madrid, José
Carolino, Elisabete
Sousa, Eva
Palavras-chave: Nuclear medicine
Reference values database
Brain single emission tomography
Parkinson disease
Data: Out-2015
Citação: Queiroga M, Silva D, Elias M, Serrano J, Carolino E, Sousa E, et al. Implementation of a new reference values database for semiquantification in123I-FP-CIT brain single emission tomography. In EANM'15 – Annual Congress of the European Association of Nuclear Medicine, Hamburg (Germany), October 10-14, 2015.
Resumo: Brain dopamine transporters imaging by Single Emission Tomography (SPECT) with 123I-FP-CIT (DaTScanTM) has become an important tool in the diagnosis and evaluation of Parkinson syndromes.This diagnostic method allows the visualization of a portion of the striatum – where healthy pattern resemble two symmetric commas - allowing the evaluation of dopamine presynaptic system, in which dopamine transporters are responsible for dopamine release into the synaptic cleft, and their reabsorption into the nigrostriatal nerve terminals, in order to be stored or degraded. In daily practice for assessment of DaTScan TM, it is common to rely only on visual assessment for diagnosis. However, this process is complex and subjective as it depends on the observer’s experience and it is associated with high variability intra and inter observer. Studies have shown that semiquantification can improve the diagnosis of Parkinson syndromes. For semiquantification, analysis methods of image segmentation using regions of interest (ROI) are necessary. ROIs are drawn, in specific - striatum - and in nonspecific – background – uptake areas. Subsequently, specific binding ratios are calculated. Low adherence of semiquantification for diagnosis of Parkinson syndromes is related, not only with the associated time spent, but also with the need of an adapted database of reference values for the population concerned, as well as, the examination of each service protocol. Studies have concluded, that this process increases the reproducibility of semiquantification. The aim of this investigation was to create and validate a database of healthy controls for Dopamine transporters with DaTScanTM named DBRV. The created database has been adapted to the Nuclear Medicine Department’s protocol, and the population of Infanta Cristina’s Hospital located in Badajoz, Spain.
Peer review: yes
URI: http://hdl.handle.net/10400.21/5339
Versão do Editor: http://eanm15.eanm.org/programme/docs/FINAL_EANM15_CTE_ABSTRACT_BOOK.pdf
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