Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/2449
Título: What do we know about the α/β for prostate cancer?
Autor: Oliveira, S. M.
Teixeira, Nuno
Fernandes, Lisete
Palavras-chave: Oncology
Prostate cancer
Alpha/beta ratio
Dose fractionation
Data: Jun-2012
Editora: American Association of Physicists in Medicine
Citação: Oliveira SM, Teixeira N, Fernandes L. What do we know about the α/β for prostate cancer? Med Phys. 2012;39(6):3189-201.
Resumo: Since last decade, the debate on the parameter which reflects prostate cancer sensitivity to fractionation in a radiotherapy treatment, the α/β, has become extensive. Unlike most tumors, the low labeling indices (LI) and large potential doubling time that characterize the prostate tumor led some authors to consider that it may behave as a late responding tissue. So far, the existing studies with regard to this subject point to a low value of α/β, around 2.7 Gy, which may be considered as a therapeutic gain in relation to surrounding normal tissues by using fewer and larger fractions. The aim of this paper is to review several estimates that have been made in the last few years regarding the prostate cancer α/β both from clinical and experimental data, as well as the set of factors that have potentially influenced these evaluations.
Peer review: yes
URI: http://hdl.handle.net/10400.21/2449
ISSN: 0094-2405
Versão do Editor: http://online.medphys.org/resource/1/mphya6/v39/i6/p3189_s1
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