Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/7669
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dc.contributor.authorTeixeira, Ricardo G.-
dc.contributor.authorBrás, Ana Rita-
dc.contributor.authorCôrte-Real, Leonor-
dc.contributor.authorTatikonda, Rajendhraprasad-
dc.contributor.authorSanches, Anabela-
dc.contributor.authorRobalo, M. Paula-
dc.contributor.authorAvecilla, Fernando-
dc.contributor.authorMoreira, Tiago-
dc.contributor.authorGarcia, M. Helena-
dc.contributor.authorHaukka, Matti-
dc.date.accessioned2017-12-07T12:05:12Z-
dc.date.available2017-12-07T12:05:12Z-
dc.date.issued2017-12-02-
dc.identifier.citationTEIXEIRA, Ricardo G.; [et al] – Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells. European Journal of Medicinal Chemistry. ISSN: 0223-5234. (2017), pp. 1-39.pt_PT
dc.identifier.issn0223-5234-
dc.identifier.urihttp://hdl.handle.net/10400.21/7669-
dc.description.abstractThree new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(η5-MeCp)(PPh3)2Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P <img height="13" border="0" style="vertical-align:bottom" width="11" alt="View the MathML source" title="View the MathML source" src="http://origin-ars.els-cdn.com/content/image/1-s2.0-S0223523417309625-si1.gif">1¯. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(η5-MeCp)(PPh3)(L1)][CF3SO3] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4–6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent.pt_PT
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147216/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147364/PTpt_PT
dc.rightsclosedAccesspt_PT
dc.subjectRuthenium methylcyclopentadienylpt_PT
dc.subjectColorectal cancerpt_PT
dc.subjectApoptosispt_PT
dc.subjectSelectivitypt_PT
dc.titleNovel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cellspt_PT
dc.typearticlept_PT
dc.peerreviewedyespt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
degois.publication.firstPage1pt_PT
degois.publication.lastPage39pt_PT
degois.publication.titleEuropean Journal of Medicinal Chemistrypt_PT
dc.relation.publisherversionhttps://ac.els-cdn.com/S0223523417309625/1-s2.0-S0223523417309625-main.pdf?_tid=bb903972-db43-11e7-9c33-00000aacb362&acdnat=1512647141_93ba39e1dea8803610923a1e6708b22dpt_PT
dc.identifier.doihttps://doi.org/10.1016/j.ejmech.2017.11.059pt_PT
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