Please use this identifier to cite or link to this item: http://hdl.handle.net/10400.21/7669
Title: Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
Author: Teixeira, Ricardo G.
Brás, Ana Rita
Côrte-Real, Leonor
Tatikonda, Rajendhraprasad
Sanches, Anabela
Robalo, M. Paula
Avecilla, Fernando
Moreira, Tiago
Garcia, M. Helena
Haukka, Matti
Keywords: Ruthenium methylcyclopentadienyl
Colorectal cancer
Apoptosis
Selectivity
Issue Date: 2-Dec-2017
Publisher: Elsevier
Citation: TEIXEIRA, Ricardo G.; [et al] – Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells. European Journal of Medicinal Chemistry. ISSN: 0223-5234. (2017), pp. 1-39.
Abstract: Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(η5-MeCp)(PPh3)2Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P <img height="13" border="0" style="vertical-align:bottom" width="11" alt="View the MathML source" title="View the MathML source" src="http://origin-ars.els-cdn.com/content/image/1-s2.0-S0223523417309625-si1.gif">1¯. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(η5-MeCp)(PPh3)(L1)][CF3SO3] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4–6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent.
Peer review: yes
URI: http://hdl.handle.net/10400.21/7669
DOI: https://doi.org/10.1016/j.ejmech.2017.11.059
ISSN: 0223-5234
Publisher Version: https://ac.els-cdn.com/S0223523417309625/1-s2.0-S0223523417309625-main.pdf?_tid=bb903972-db43-11e7-9c33-00000aacb362&acdnat=1512647141_93ba39e1dea8803610923a1e6708b22d
Appears in Collections:ISEL - Eng. Quim. Biol. - Artigos

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