Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/763
Título: Micronuclei in peripheral blood lymphocytes in formaldehyde occupationally exposed workers
Autor: Ladeira, Carina
Viegas, Susana
Prista, João
Malta-Vacas, Joana
Gomes, Mário
Mendonça, Paula
Brito, Miguel
Palavras-chave: Anatomia patológica
Saúde ocupacional
Formaldeído
Cancro nasofaríngeo
Data: Jul-2011
Citação: Ladeira C, Viegas S, Prista J, Malta-Vacas J, Gomes MC, Mendonça P, Brito M. Micronuclei in peripheral blood lymphocytes in formaldehyde occupationally exposed workers. In XII IUTOX - International Congress of Toxicology, Barcelon (Spain), 19th to 23rd July 2011. Poster.
Resumo: Formaldehyde (CH2O) the most simple and reactive of all aldehydes, is a colorless, reactive and readily polymerizing gas at normal temperature. It has a pungent, suffocating odour that is recognized by most human subjects at concentrations below 1 ppm. According to the Report on Carcinogens, formaldehyde (FA) ranks 25th in the overall U.S. chemical production with more than 11 billion pounds (5 million tons) produced each year. Is an important industrial compound that is used in the manufacture of synthetic resins and chemical compounds such as lubricants and adhesives. It has also applications as a disinfectant, preservative and is used in cosmetics. Estimates of the number of persons who are occupationally exposed to FA indicate that, at least at low levels, may occur in a wide variety of industries. The occupational settings with most extensive use of formaldehyde is in the production of resins and in anatomy and pathology laboratories. Several studies reported a carcinogenic effect in humans after inhalation of FA, in particular an increased risk for nasopharyngeal cancer. Nowadays, the International Agency for Research on Cancer (IARC) classifies FA as carcinogenic to humans (group 1), on the basis of sufficient evidence in humans and sufficient evidence in experimental animals. Manifold in vitro studies clearly indicated that FA is genotoxic. FA induced various genotoxic effects in proliferatin cultured mammalian cells. A variety of evidence suggests that the primary DNA alterations after FA exposure are DNA-protein crosslinks (DPX). Incomplete repair of DPX can lead to the formation of mutations.
Peer review: yes
URI: http://hdl.handle.net/10400.21/763
Aparece nas colecções:ESTeSL - Posters

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