Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/758
Título: Effects of the interaction of tobacco smoke and alcohol consumption on buccal micronucleus in workers exposed occupationally to formaldehyde
Autor: Ladeira, Carina
Viegas, Susana
Carolino, Elisabete
Prista, João
Gomes, Manuel C.
Brito, Miguel
Palavras-chave: Anatomia patológica
Saúde ocupacional
Formaldeído
Cancro nasofaríngeo
Consumo de álcool
Tabagismo
Data: Mai-2010
Citação: Ladeira C, Viegas S, Carolino E, Prista J, Gomes MC, Brito M. Effects of the interaction of tobacco smoke and alcohol consumption on buccal micronucleus in workers exposed occupationally to formaldehyde. Poster.
Resumo: Occupational exposure to formaldehyde (FA) has been shown to induce nasopharyngeal cancer and has been classified as carcinogenic to humans (group 1) on the basis of sufficient evidence in humans. Tobacco smoke has been associated to a higher risk of development of cancer, especially in the oral cavity, larynx and lungs, as these are places of direct contact with many carcinogenic tobacco’s compounds. Alcohol is a recognized agent that influence cells in a genotoxic form, been citied as a strong agent with potential in the development of carcinogenic lesions. Epidemiological evidence points to a strong synergistic effect between cigarette smoking and alcohol consumption in the induction of cancers in the oral cavity. Approximately 90% of human cancers originate from epithelial cells. Therefore, it could be argued that oral epithelial cells represent a preferred target site for early genotoxic events induced by carcinogenic agents entering the body via inhalation and ingestion. The MN assay in buccal cells was also used to study cancerous and precancerous lesions and to monitor the effects of a number of chemopreventive agents.
Peer review: yes
URI: http://hdl.handle.net/10400.21/758
Aparece nas colecções:ESTeSL - Posters

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